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774 results found

Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These symptoms can have a significant impact on their risk of suicide, prognosis, and overall quality of life. The fact that depressive and negative symptoms in schizophrenia have a lot in common…

Project Ongoing

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Brain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Rising Stars Trainee Awards

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD). rTMS applies a series of pulses to the prefrontal cortex, leading to changes…

Project Ongoing

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Defective protein translation: a causative pathway in ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. ALS causes motor neurons to deteriorate and die, leading to muscle control loss. ALS patients lose control of the muscles needed to move, speak, eat, and breathe,…

Project Ongoing

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Characterizing the effects of blocking TDP-43 SUMOylation during cellular stress and recovery using live-cell imaging

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called "SUMOylation" that helps prevent the clumping of TDP-43. We created a mouse model where we disrupted SUMOylation and observed that these…

Project Ongoing

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A combined in-vivo ex-vivo approach to investigate imaging biomarkers in ALS diagnosis and aetiology

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death. While it is known that patients with ALS experience changes in certain brain regions visible on imaging, the relationships between these imaging markers and the underlying mechanisms of…

Project Ongoing

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