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676 results found

Apolipoprotein receptor 2 in AD-related brain vessel dysfunction

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Alberta

  • Start Date

    2024

  • Total Grant Amount

    $199,300

  • Health Canada Contribution

    $81,500

Project Overview

What is the role of apolipoprotein receptor 2, a protein found in the brain vessels, in Alzheimer's disease ? The brain vascular system is critical to supply the necessary energy and control the transport of molecules in and out of the brain. Failure of this system is seen early in…

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Examining vascular risk and menopausal age on women’s increased risk for AD

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $199,540

  • Health Canada Contribution

    $90,700

Project Overview

Two-thirds of individuals suffering from Alzheimer’s disease are women. The reason for women’s increased risk of Alzheimer's disease is unknown. Menopause occurs when a decline in a hormone called estrogen causes middle-aged women to stop having menstrual periods. Early menopause can increase the risk of Alzheimer's disease. Vascular conditions, such…

Project Ongoing

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Targeting KCC2 for rescuing functional impairments in Alzheimer’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $200,000

  • Health Canada Contribution

    $100,000

Project Overview

Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory signals is vital for the brain to function. Many components maintain this balance, but one key player is the protein KCC2. As levels of KCC2 are…

Project Ongoing

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Self-disclosure about dementia on social media: evidence-informed guidance

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $149,666

  • Health Canada Contribution

    $68,031

Project Overview

Individuals who engage on social media often disclose a personal dementia diagnosis or identify as a caregiver, yet little is known about the impact of that disclosure. The goal of this project is to address this gap and develop a resource to support users to navigate social media. We will…

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A Drug Screening Assay to Reduce LINGO-1 Amounts in Neurons

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $150,000

  • Health Canada Contribution

    $75,000

Project Overview

The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and myelination. LINGO-1 inhibition increases survival of multiple neural types and improves spatial learning, memory, and cognitive abilities in multiple mouse models. Thus, we hypothesize…

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