720 results found
Designing synthetic extracellular matrices to support neurodegenerative disease modeling
Project Overview
We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced pluripotent stem cells (hiPSCs) have revolutionized disease modeling and drug discovery. Enhanced 2D and 3D culture models have tremendous potential to enable hiPSC development with greater cellular maturity compared to…
Project Ongoing
See the project and researchersIn-vivo CAR-T Therapy for Glioblastoma by Novel Non-Viral Gene Editing System
Project Overview
Challenge CAR-T therapies have delivered promising results for certain hematological cancers but remain largely ineffective for solid tumours with failure nodes including complex and hostile tumor microenvironments and the lack of adapted technological tools. We propose to adapt a novel gene editing system to develop an in-vivo CAR-T gene editing…
Project Ongoing
See the project and researchersMyelin loss and cognitive impairment following SARS-CoV-2 infection
Project Overview
Does SARS-CoV-2 infection increase cognitive decline via myelin loss in older individuals? Background: One in 4 persons infected with SARS-CoV-2 (the COVID-19 virus) shows cognitive decline. This decline could be related to white matter damage. The white matter is made of axons connecting neurons with each other. The integrity of…
Project Ongoing
See the project and researchersCODEX Trial
Project Overview
Each year, over 312 million patients undergo surgery. Anesthesia is a drug-induced reversible, comatose state that facilitates surgery. It is widely assumed cognition returns to baseline afterwards. Surgery and anesthesia induce stress responses in the body, potentially damaging brain cells. Many patients develop postoperative neurocognitive disorders (PND), including delirium (fluctuating…
Project Ongoing
See the project and researchersThe CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT): Building a Research, Practice and Policy Foundation
Project Overview
A new national initiative funded by the Canadian Cancer Society, the Canadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT), is bringing together researchers, clinicians, policymakers, and people living with advanced cancer to explore the potential of psychedelic-assisted therapy as a transformative approach to cancer care. People with advanced cancer often experience…