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676 results found

Molecular processes underlying neuromuscular junction denervation in humans with ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Clinical Research Fellowship 2024

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $174,000

  • Health Canada Contribution

    $87,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). This can be one of the earliest pathological processes observed in ALS. Past investigations demonstrated NMJ dysfunction and a period of denervation-reinnervation cycling occurs before motor neuron loss. Additionally, some evidence suggests the rescue of motor…

Routine enfant TDAH Phase 2

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    MEDTEQ x Brain Canada Beachhead Program

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $889,622

  • Health Canada Contribution

    $394,662

Project Overview

“La bonne intervention, au bon moment, pour le bon enfant”. Le bien-être et l’amélioration des capacités adaptatives des enfants ayant des troubles du neurodéveloppement nécessitent des interventions personnalisées dans le temps, l’intensité, les modalités, Malheureusement, bien que ce principe soit très largement reconnu, la réalité des enfants et de leur…

Functional connectivity-guided rTMS for personalized treatment of apathy

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $199,392

  • Health Canada Contribution

    $81,542

Project Overview

Nearly half the people affected with Alzheimer’s disease will at some point show reduced motivation to perform their daily activities or participate in activities they previously enjoyed. They may also show fewer emotions or self-initiative in their daily lives. Such a reduction in behavior is termed as apathy and affects…

Dynamic interplay of vascular injury and inflammation on AD progression

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $159,920

  • Health Canada Contribution

    $63,600

Project Overview

Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied to the brain. Such vascular damage can increase the risk of Alzheimer's disease (AD) by up to three times. The brain has specialized immune cells, called astrocytes and microglia,…

Measuring and Improving the Quality of Community-Based Dementia Care

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Advancing Research on Care and Outcome Measurement (ARCOM)

  • Province

    Alberta

  • Start Date

    2024

  • Total Grant Amount

    $226,900

  • Health Canada Contribution

    $113,450

Project Overview

There are an increasing number of people living with dementia. Improving and maintaining quality of life is rated as the highest priority for people living with dementia and their caregivers. While many factors contribute to quality of life, high quality health care is an important component of optimizing quality of…