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676 results found

Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in metabolic pathways confer altered metabolic function by increasing production of the oncogenic metabolite R-2-Hydroxyglutarate (R-2HG). This metabolite was shown to promote…

Project Ongoing

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Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour's molecular makeup and found three subtypes with different survival rates. One subtype, called "Ciliary," stands out because of…

Project Ongoing

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Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These symptoms can have a significant impact on their risk of suicide, prognosis, and overall quality of life. The fact that depressive and negative symptoms in schizophrenia have a lot in common…

Project Ongoing

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Brain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Rising Stars Trainee Awards

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD). rTMS applies a series of pulses to the prefrontal cortex, leading to changes…

Project Ongoing

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Defective protein translation: a causative pathway in ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. ALS causes motor neurons to deteriorate and die, leading to muscle control loss. ALS patients lose control of the muscles needed to move, speak, eat, and breathe,…

Project Ongoing

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