720 results found
Stress granules: neuroprotective or neurotoxic in ALS pathogenesis?
Project Overview
ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones. With the exception of SOD1 families, despite decades of research, we have yet to identify a truly disease-modifying therapy for ALS. We believe that this is due not…
Project Ongoing
See the project and researchersStudying the involvement of cell surface RNA binding proteins in ALS pathogenesis
Project Overview
Amyotrophic lateral sclerosis (known as ALS or Lou Gehrig’s disease) is a debilitating disease that causes loss of control over muscles and leads to death quickly after diagnosis. In Canada, each year approximately 1000 people die of ALS and a similar number of people are newly diagnosed with this disease.…
Project Ongoing
See the project and researchersInvestigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids
Project Overview
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. In addition to the selective loss of nerve cells controlling muscle movements, buildup of protein aggregates can also be seen in affected nerve cells of ALS patients. Mounting evidence…
Project Ongoing
See the project and researchersInvestigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models
Project Overview
While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. In these children, the disease course is longer but nevertheless results in loss of control of muscles. It is not known why ALS manifests at younger…
Project Ongoing
See the project and researchersLate stage pre‐clinical development of a small molecule compound for re‐myelination and functional recovery in multiple sclerosis through disruption of the AMPA‐GAPDH complex
Project Overview
While it is the immune system that damages the brain in MS, the way this damage is caused involves many processes. One such process is called excitotoxicity, which is when the chemicals brain cells use to communicate can become toxic to those cells. We have a new drug which stops…