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Selection of DNA Aptamers for Inhibition of Protein Aggregation in ALS
Project Overview
The fight against ALS is made extremely challenging due to its largely unknown origin in most patients. This is the case for sporadic ALS, which accounts for up to 90% of all ALS cases, leaving this cohort of patients searching for answers. Our proposal aims to tackle one of the…
Project Ongoing
See the project and researchersStress granules: neuroprotective or neurotoxic in ALS pathogenesis?
Project Overview
ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones. With the exception of SOD1 families, despite decades of research, we have yet to identify a truly disease-modifying therapy for ALS. We believe that this is due not…
Project Ongoing
See the project and researchersStudying the involvement of cell surface RNA binding proteins in ALS pathogenesis
Project Overview
Amyotrophic lateral sclerosis (known as ALS or Lou Gehrig’s disease) is a debilitating disease that causes loss of control over muscles and leads to death quickly after diagnosis. In Canada, each year approximately 1000 people die of ALS and a similar number of people are newly diagnosed with this disease.…
Project Ongoing
See the project and researchersInvestigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids
Project Overview
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. In addition to the selective loss of nerve cells controlling muscle movements, buildup of protein aggregates can also be seen in affected nerve cells of ALS patients. Mounting evidence…
Project Ongoing
See the project and researchersInvestigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models
Project Overview
While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. In these children, the disease course is longer but nevertheless results in loss of control of muscles. It is not known why ALS manifests at younger…