720 results found
Transforming Palliative Care for People Living with Advanced Cancer: Developing a National Research Platform
Project Overview
Palliative care (PC) is an area of medicine that focuses on symptom control and quality of life of patients with life-limiting illnesses and their families. PC can be provided at any point in the cancer experience, even alongside cancer treatments. PC can improve symptoms and quality of life, but the…
Project Ongoing
See the project and researchersNovel Repetitive Transcranial Magnetic Stimulation Paradigm to Reduce Cortical Hyperexcitability in Patients with ALS
Project Overview
ALS is a devastating neurological disease characterized by the progressive degeneration of motor neurons leading to paralysis and death. Although the exact cause of ALS remains unknown in the majority of patients, abnormalities in the motor cortex of the brain can be detected early in the disease and may be…
Project Ongoing
See the project and researchersA multi-methods multi-site study of end-of-life care in individuals with ALS: goal concordance and caregiver perceptions
Project Overview
Amyotrophic lateral sclerosis (ALS) is a terminal disease of nerves and muscles. From the time of symptom onset, people with ALS live about 3-5 years. Death results in significant grief in their caregivers. Previous research has shown where people with ALS are dying, but none have shown where they want…
Project Ongoing
See the project and researchersExploring a therapeutic approach to promote neuronal function for ALS
Project Overview
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases which have overlap in pathological features and the genetic basis. We recently discovered that treating mouse neurons Analysis of neurons isolated from mice which carry a genetic alteration associated with human ALS/FTD, revealed a variety of defects…
Project Ongoing
See the project and researchersSelection of DNA Aptamers for Inhibition of Protein Aggregation in ALS
Project Overview
The fight against ALS is made extremely challenging due to its largely unknown origin in most patients. This is the case for sporadic ALS, which accounts for up to 90% of all ALS cases, leaving this cohort of patients searching for answers. Our proposal aims to tackle one of the…