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676 results found

Unravelling Molecular Mechanisms of ALS: Characterizing the in vitro and in vivo effects of biometals on the ALS-linked proteins TDP-43, SOD1, PGRN, and MFSD8

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, typically resulting from gene mutations that facilitate abnormal protein aggregation. Studies suggest that mutations in several proteins including TDP-43, SOD1, PGRN, and MFSD8, are linked to familial and sporadic cases of ALS (fALS/sALS). In…

Project Ongoing

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Multi-modal neuroimaging biomarkers of Parkinson’s disease progression

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world. PD can manifest and develop in a variety of ways for different patients, and it is currently not possible to reliably determine, for a given patient, which subtype of PD they have and what course their…

Project Ongoing

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The effects of different types of exercise on sleep quality and architecture in people with Parkinson’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Most people with Parkinson's Disease (PD) suffer from sleep problems and show marked alterations in sleep architecture (i.e., the basic structural organization of normal sleep). These alterations are clinically relevant because they increase the risk of developing age-related cognitive problems and dementia and can accelerate the motor deterioration of the…

Project Ongoing

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TACAN regulates mesenchymal versus amoeboid cell states in glioblastoma

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Current treatment includes surgical resection, chemotherapy, and radiation. However, since GBM is fastgrowing and highly invasive, existing therapies often result in tumour recurrence and poor survival outcomes, emphasizing the importance of the development of novel therapeutic targets.…

Project Ongoing

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Neuro-immunity in glioma and melanoma brain metastasis

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Melanoma brain metastases (MBMs) are a serious issue affecting up to half of all patients with stage IV melanoma, typically leading to a poor outlook. While immune therapy using anti-PD-1 can help, it only works for about 20% of MBM patients, which is much lower than the response seen in…

Project Ongoing

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