720 results found
Characterizing regional cerebral autoregulation in women with carotid stenosis and its relationship to underlying hemodynamic and metabolic function
Project Overview
The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral blood flow (CBF) regulation in different regions of their brain. Specifically, we hypothesize that women with more severe CAS will have greater impairments in their ability to maintain CBF during rapid reductions in…
Project Ongoing
See the project and researchersInvestigating the relationship between vascular risk factors and cognitive impairment in Canadian women from ethnically diverse groups
Project Overview
To obtain a more inclusive understanding of vascular contributions to cognitive impairment and dementia (VCID) in women, we will investigate the relationship between vascular health and cognition in women belonging to Canada’s three largest ethnic groups (South Asian, Chinese, and White). To do so, we will assess measures of vascular…
Project Ongoing
See the project and researchersSex Differences in Association between hypertension and Cognitive Health: The Role of Small Vessel Disease
Project Overview
The understanding of the factors responsible for the increased risk of cognitive problems in women remains limited. Determining the function of small vessel disease in maintaining brain health is crucial, particularly for women. As a result, we propose examining cognitive abilities as well as changes in the structure and volume…
Project Ongoing
See the project and researchersThe effects of intensity and volume of physical activity on cerebrovascular health in women across the menopausal transition
Project Overview
Our research project will investigate the relationship between physical activity and brain vascular health in women. The term vascular brain health refers to the health of blood vessels within the brain. To measure brain vascular health, we use cerebrovascular reactivity (CVR) which quantifies the abilities of blood vessels to expand…
Project Ongoing
See the project and researchersMolecular processes underlying neuromuscular junction denervation in humans with ALS
Project Overview
Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). This can be one of the earliest pathological processes observed in ALS. Past investigations demonstrated NMJ dysfunction and a period of denervation-reinnervation cycling occurs before motor neuron loss. Additionally, some evidence suggests the rescue of motor…