720 results found
Zebrafish as a novel animal model for the study of Zika virus neuropathogenesis in vivo
Project Overview
Infections with Zika virus (ZIKV) constitute a major global public health concern worldwide. Indeed, the recent ZIKV outbreak in the Americas revealed that infection of pregnant women can lead to congenital transmission, infection within the fetal developing brain and eventually to microcephaly in the infant. Most importantly, no antiviral therapies…
Project Ongoing
See the project and researchersDirect microglial reprogramming to study Parkinson’s Disease
Project Overview
The human brain is a complex organ that presents many challenges for neuroscientists. For instance, tissue availability represents a major problem given that this organ does not regenerates, making it next to impossible to obtain live tissue from patients that would allow to study how cells in the brain change…
Project Complete
See the project and researchersDopaminergic modulation of stroke recovery
Project Overview
Strokes often cause brain damage that affects normal cognitive and sensorimotor functions. The brain has the extraordinary ability to adapt by forming new circuits which can, to some extent, compensate for neuronal loss. The recovery of motor function can be improved by rehabilitation exercises aimed at strengthening the brain and…
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See the project and researchersMolecular origins of childhood brain cancer
Project Overview
Pediatric high-grade gliomas are incurable brain cancers. Sequencing the tumor specimens has shown that most cases do not have obvious mutations that are known to cause cancer. It is therefore not known what causes, or "drives," these cancers. Identifying cancer drivers is a fundamental step in designing new treatments. We…
Project Complete
See the project and researchersIndividually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation
Project Overview
Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy. In keeping with the tenets of Personalized Medicine, treatments should be tailored to individual therapeutic needs as opposed to treating all patients with the same approach. In Neurodegeneration, unfortunately,…