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661 results found

The Profile and Trajectory of Brain Tumours across the Continuum of Care in Ontario, Canada: A Population Based Study

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $30,000

  • Health Canada Contribution

    $15,000

Project Overview

This study will provide more in-depth information on all individuals with malignant and benign brain tumours in Ontario and their utilization of health care services at the provincial and local level. The objectives of this project are to (1) identify the number of persons with brain tumour and the associated…

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Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Developmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC). Among these pathways, Hippo and Wnt signal transduction are implicated in the growth of glioma…

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Nonlinear MR-US Registration for Image Guided Neurosurgery of Brain Tumours

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Québec

  • Start Date

    2013

  • Total Grant Amount

    $105,000

  • Health Canada Contribution

    $52,500

Project Overview

The broad aim of this project is to develop and evaluate nonlinear registration techniques that account for discontinuities in data from tissue resection in order to accurately reflect the deformed brain. These registration procedures will improve patient-image alignment during surgery and enable correction of preoperative data to reflect the intraoperative…

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Identification of Brain Metastasis Initiating Cells and Regulators of Brain Metastasis from Lung Cancer

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $105,000

  • Health Canada Contribution

    $52,500

Project Overview

A recent study by the Massague group has identified genes that mediated breast cancer metastasis to the brain by using genomic expression analysis to compare in vivo-selected brain metastasis cell lines to the corresponding parental lines. Knockdown of these genes reduced the migration and invasiveness of BM-derived cells in vitro…

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Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Although it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated. Specifically, it remains unknown whether miRNAs and LncRNAs, have other…

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