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Deepening our understanding of G3BP1 and its paralog G3BP2 to facilitate accurate therapeutic development for ALS/FTD
https://braincanada.ca/fr/subventions-financées/deepening-our-understanding-of-g3bp1-and-its-paralog-g3bp2-to-facilitate-accurate-therapeutic-development-for-als-ftdWhile significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective therapy to significantly slow...
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Defective protein translation: a causative pathway in ALS
https://braincanada.ca/fr/subventions-financées/defective-protein-translation-a-causative-pathway-in-alsAmyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. Project Overview Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with...
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Defective protein translation: a causative pathway in ALS?
https://braincanada.ca/fr/subventions-financées/defective-protein-translation-a-causative-pathway-in-als-2Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...
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Defining and targeting clonal hematopoiesis as a driver of glioblastoma growth
https://braincanada.ca/fr/subventions-financées/defining-and-targeting-clonal-hematopoiesis-as-a-driver-of-glioblastoma-growthWe discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP. Project Overview We discovered that approximately one fifth of people with the deadly brain tumour...
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Defining conserved functions of RNA binding proteins in stress-granule biogenesis
https://braincanada.ca/fr/subventions-financées/defining-conserved-functions-of-rna-binding-proteins-in-stress-granule-biogenesisRNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Project Overview RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to...
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Defining the role of primary cilia in shaping astrocyte development and response to brain insults
https://braincanada.ca/fr/subventions-financées/defining-the-role-of-primary-cilia-in-shaping-astrocyte-development-and-response-to-brain-insultsAstrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. Project Overview Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. It is increasingly...
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Dementia Talks! Canada
https://braincanada.ca/fr/subventions-financées/dementia-talks-canadaPartners and Donors Alzheimer Society of Canada
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Des projets pour les enfants et jeunes atteints de troubles neurodéveloppementaux
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/des-projets-pour-les-enfants-et-jeunes-atteints-de-troubles-neurodéveloppementauxEn partenariat avec Brain Canada, le Réseau sur la santé du cerveau des enfants (RSCE) a le plaisir d’annoncer cinq nouveaux projets d’innovation et de mise en œuvre pour améliorer la vie des enfants et des jeunes atteints de troubles neurologiques, ainsi que celle de leur famille, dans tout le...
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Des résultats à l’intersection des neurosciences et de l’IA
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/impact-au-carrefour-des-neurosciences-et-de-l-intelligence-artificielleDans le cadre de sa mission de financement de la recherche audacieuse sur le cerveau, la Fondation Brain Canada, en collaboration avec ses donatrices et donateurs et ses partenaires, a soutenu des douzaines de projets et de plateformes de recherche à grande échelle afin de développer et de mettre en...
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Design and Development of Analogues of beta-Alanine as Therapeutics for AD
https://braincanada.ca/fr/subventions-financées/design-and-development-of-analogues-of-beta-alanine-as-therapeutics-for-adWhen brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. Project Overview When brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. This study’s objective is to design...