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Identifying the cell-type specific transcriptional program by Npas4 in motor learning
https://braincanada.ca/fr/subventions-financées/identifying-the-cell-type-specific-transcriptional-program-by-npas4-in-motor-learningThe primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of the sites for motor memory formation and storage. Project Overview The primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of...
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Imaging a New ALS Biomarker in the Eye
https://braincanada.ca/fr/subventions-financées/imaging-a-new-als-biomarker-in-the-eyeCurrent biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost, accessibility, and invasiveness of procedures. Project Overview Current biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost,...
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Imaging Endocannabinoid Signalling in Individuals with Cocaine Addiction
https://braincanada.ca/fr/subventions-financées/imaging-endocannabinoid-signalling-in-individuals-with-cocaine-addictionCocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Project Overview Cocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Demand for the drug is growing and rates of...
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Immunotherapy as a targeted low-impact treatment of paediatric brain cancers
https://braincanada.ca/fr/subventions-financées/immunotherapy-as-a-targeted-low-impact-treatment-of-paediatric-brain-cancersThe existing treatment regimens for children with ependymomas are generally not successful and if successful survivors are left with considerable disabilities including severely diminished IQ, focal neurological and language deficits, and endocrine deficiencies. Project Overview The existing...
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Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence
https://braincanada.ca/fr/subventions-financées/impact-of-2-hydroxyglutarate-induced-astrocytes-reactivity-in-low-grade-glioma-progression-and-recurrenceMutations in the metabolic enzymes are commonly observed in brain cancers. Project Overview Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in...
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Impact of brain trauma in childhood on white matter maturation
https://braincanada.ca/fr/subventions-financées/impact-of-brain-trauma-in-childhood-on-white-matter-maturationAn enormous amount of brain development occurs throughout childhood and experiencing a concussion during this time may have long-lasting effects. Project Overview An enormous amount of brain development occurs throughout childhood and experiencing a concussion during this time may have long-lasting...
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Impaired Neuromuscular Junction Connectivity in Amyotrophic Lateral Sclerosis
https://braincanada.ca/fr/subventions-financées/impaired-neuromuscular-junction-connectivity-in-amyotrophic-lateral-sclerosisMany scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place where motor neurons connect to muscle, known as the neuromuscular junction (NMJ). Project Overview Many scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place...
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Impaired orexin activity as a mediator of isolation-induced social anxiety
https://braincanada.ca/fr/subventions-financées/impaired-orexin-activity-as-a-mediator-of-isolation-induced-social-anxietyWe live in a world profoundly shaped by social behaviours involving interactions and communications between conspecifics of a given species. Project Overview We live in a world profoundly shaped by social behaviours involving interactions and communications between conspecifics of a given species....
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Impaired translational regulation of brain development in autism spectrum disorders
https://braincanada.ca/fr/subventions-financées/impaired-translational-regulation-of-brain-development-in-autism-spectrum-disordersAutism spectrum disorders (ASDs) are a group of complex neurodevelopmental disorders with distinguished early emerging behavioral disruptions (speech impairments, social communication, repetitive behaviors) and a rising rate of diagnosis to an estimated 1 in 68 children. Project Overview Autism...
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Implementation of a Clinical Pathway for Acute Care of Pediatric Concussion: Uptake, Outcomes, and Health Care Impacts
https://braincanada.ca/fr/subventions-financées/implementation-of-a-clinical-pathway-for-acute-care-of-pediatric-concussion-uptake-outcomes-and-health-care-impactsEach year, 1-2 million children in North America suffer a concussion. Project Overview Each year, 1-2 million children in North America suffer a concussion. Guidelines exist to manage the care of concussion in children but have not been implemented consistently. As a result, clinical practice...