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Diagnostiquer l'autisme chez les plus jeunes
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/diagnostiquer-l-autisme-chez-les-patients-les-plus-jeunesPlus d'une personne sur cent est atteinte d'un trouble du spectre autistique (TSA), ce qui a de profondes répercussions sur la qualité de vie des personnes concernées et de leurs familles. De nombreux parents d'enfants atteints de TSA identifient des problèmes dès l'âge de 12 à 18 mois, mais l'âge...
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DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)
https://braincanada.ca/fr/subventions-financées/digital-markers-of-social-cognition-for-diagnosis-prognosis-in-neurodegeneration-discernImpairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Project Overview Impairments in...
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DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)
https://braincanada.ca/fr/subventions-financées/digital-markers-of-social-cognition-for-diagnosis-prognosis-in-neurodegeneration-discern-2Impairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Project Overview Impairments in...
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Direct microglial reprogramming to study Parkinson’s Disease
https://braincanada.ca/fr/subventions-financées/direct-microglial-reprogramming-to-study-parkinson-s-diseaseThe human brain is a complex organ that presents many challenges for neuroscientists. Project Overview The human brain is a complex organ that presents many challenges for neuroscientists. For instance, tissue availability represents a major problem given that this organ does not regenerates,...
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Discovering “hidden” causal mutations in autism using long-read RNAseq and proteomics in neuron development
https://braincanada.ca/fr/subventions-financées/discovering-hidden-causal-mutations-in-autism-using-long-read-rnaseq-and-proteomics-in-neuron-developmentAutism spectrum disorder (ASD) is a complex condition affecting communication, social interactions, and behavior in approximately 1–2% of people worldwide. Project Overview Autism spectrum disorder (ASD) is a complex condition affecting communication, social interactions, and behavior in...
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Discovering how brain cancer evolution affects responses to treatment
https://braincanada.ca/fr/subventions-financées/discovering-how-brain-cancer-evolution-affects-responses-to-treatmentA type of brain cancers called “diffuse gliomas” currently lacks effective treatments. Project Overview A type of brain cancers called “diffuse gliomas” currently lacks effective treatments. One obstacle to developing new therapies is the disease variability between patients. Several categories of...
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Discovery of Therapeutic Targets for FUS- and TDP43-Dependent Forms of ALS
https://braincanada.ca/fr/subventions-financées/discovery-of-therapeutic-targets-for-fus-and-tdp43-dependent-forms-of-alsThe four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72 Project Overview The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72. Of these, TDP-43 and FUS have the most in common. Not only do they share similar functions inside cells, but in motor neurons...
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Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS
https://braincanada.ca/fr/subventions-financées/discovery-of-transcriptomic-biomarkers-and-epigenetic-therapeutic-targets-for-c9als-and-salsDr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. Project Overview Dr. Belzil began her research career as a PhD student at the...
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Disrupted SUMOylation facilitates rogue TDP-43 in ALS
https://braincanada.ca/fr/subventions-financées/disrupted-sumoylation-facilitates-rogue-tdp-43-in-alsProteins are large molecules that play many essential roles in the body. Project Overview Proteins are large molecules that play many essential roles in the body. They do most of the work inside cells and are necessary for the structure, function and regulation of all tissues and organs. TDP-43 is...
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Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach
https://braincanada.ca/fr/subventions-financées/disrupting-vcp-p97-glua1-as-a-novel-therapeutic-intervention-to-restore-synaptic-plasticity-in-alzheimer-s-disease-a-cryo-electron-microscopy-cryo-em-based-approachMany proteins in our brain are responsible for memory and learning. Project Overview Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas...