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Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients. Project Overview Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients. A promising avenue to overcome this deficit is the recently described...

The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Project Overview The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Such promoters are...

The CIFAR Humans & the Microbiome program brings together 21 researchers to examine what consciousness is and how it comes about. Project Overview The CIFAR Humans & the Microbiome program brings together 21 researchers to examine what consciousness is and how it comes about. The program is part of...

A recent study by the Massague group has identified genes that mediated breast cancer metastasis to the brain by using genomic expression analysis to compare in vivo-selected brain metastasis cell lines to the corresponding parental lines. Project Overview A recent study by the Massague group has...

Earlier diagnosis of ALS remains one of the biggest goals of researchers worldwide and it is likely that the effectiveness of future treatment discoveries will be magnified by their application at a time point closer to symptom onset. Project Overview Earlier diagnosis of ALS remains one of the...

Amyotrophic Lateral Sclerosis (ALS) can result from many different mutations in the same gene, making mutation-specific treatments challenging. Project Overview Amyotrophic Lateral Sclerosis (ALS) can result from many different mutations in the same gene, making mutation-specific treatments...

Stroke is the leading cause of disability among adults and one of the three leading causes of death in North America. Project Overview Stroke is the leading cause of disability among adults and one of the three leading causes of death in North America. Intracranial aneurysm (IA) is one of the main...

Amyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. Project Overview Amyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. A common hallmark of its familial and sporadic forms is the accumulation of insoluble protein aggregates in the cytoplasm of motor...

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. Project Overview People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These...

Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. Project Overview Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. It occurs when the immune...