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Investigating a putative modifier of HTT toxicity using cellular assays
https://braincanada.ca/fr/subventions-financées/investigating-a-putative-modifier-of-htt-toxicity-using-cellular-assaysPartners and Donors Huntington Society of Canada
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Investigating altered functional brain networks in autism spectrum disorder
https://braincanada.ca/fr/subventions-financées/investigating-altered-functional-brain-networks-in-autism-spectrum-disorderAutism Spectrum Disorder (ASD) is a complex developmental brain disorder characterised by impaired communication and repetitive behaviors, and is often accompanied by intellectual disability. Project Overview Autism Spectrum Disorder (ASD) is a complex developmental brain disorder characterised by...
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Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging
https://braincanada.ca/fr/subventions-financées/investigating-blood-brain-barrier-permeability-in-an-experimental-model-of-juvenile-stroke-using-advanced-mr-imagingStroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences. Project Overview Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences. Currently, treatment of childhood...
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Investigating cerebellar pathology in a zebrafish C9orf72 ALS model
https://braincanada.ca/fr/subventions-financées/investigating-cerebellar-pathology-in-a-zebrafish-c9orf72-als-modelAmyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by...
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Investigating Ciliary Defects in Rett Syndrome Neurons
https://braincanada.ca/fr/subventions-financées/investigating-ciliary-defects-in-rett-syndrome-neuronsRett syndrome (RTT) is a severe neurological disorder that primarily affects girls, occurring in about 1 in 10,000 births. Project Overview Rett syndrome (RTT) is a severe neurological disorder that primarily affects girls, occurring in about 1 in 10,000 births. Children with RTT experience...
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Investigating claustrocortical circuit function in sleep
https://braincanada.ca/fr/subventions-financées/investigating-claustrocortical-circuit-function-in-sleepA memory is perhaps the most fragile and personal of all our possessions. Project Overview A memory is perhaps the most fragile and personal of all our possessions. The ability to form and retrieve an episodic memory requires a very complex set of neurobiological processes in the brain. Although...
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Investigating disease progression and survival outcomes in ALS patients using deep learning and deformation based morphometry
https://braincanada.ca/fr/subventions-financées/investigating-disease-progression-and-survival-outcomes-in-als-patients-using-deep-learning-and-deformation-based-morphometryAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to...
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Investigating inhibition of TDP-43 propagation as a therapeutic strategy for ALS
https://braincanada.ca/fr/subventions-financées/investigating-inhibition-of-tdp-43-propagation-as-a-therapeutic-strategy-for-alsIt is not known why ALS is a rapidly progressing disease. Project Overview It is not known why ALS is a rapidly progressing disease. The discovery that the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) is a pathological hallmark of sporadic ALS and a subset of frontotemporal lobar...
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Investigating localized proteostasis to sustain synaptic plasticity
https://braincanada.ca/fr/subventions-financées/investigating-localized-proteostasis-to-sustain-synaptic-plasticityThe mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Project Overview The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Synapses are plastic and adapt their...
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Investigating mechanisms of altered lipid droplet dynamics in ALS
https://braincanada.ca/fr/subventions-financées/investigating-mechanisms-of-altered-lipid-droplet-dynamics-in-alsIn Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. Project Overview In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or...