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Investigating mechanisms that cause mitochondrial dysfunction and synaptic loss
https://braincanada.ca/fr/subventions-financées/investigating-mechanisms-that-cause-mitochondrial-dysfunction-and-synaptic-lossAmyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement. Project Overview Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s...
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Investigating Myelin Modulation by Psychoplastogens as a Novel Mechanism for Sustained Therapeutic Outcomes in Neuropsychiatric Disorders
https://braincanada.ca/fr/subventions-financées/investigating-myelin-modulation-by-psychoplastogens-as-a-novel-mechanism-for-sustained-therapeutic-outcomes-in-neuropsychiatric-disordersPsychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression. Project Overview Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression....
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Investigating S-Nitrosylation of MCUB in Mitochondrial Calcium Dysregulation and Huntington’s Disease
https://braincanada.ca/fr/subventions-financées/investigating-s-nitrosylation-of-mcub-in-mitochondrial-calcium-dysregulation-and-huntington-s-disease"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline." Project Overview “Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and...
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Investigating Spike-Timing Dependent Plasticity Mechanisms of Memory Consolidation with Multiscale Hippocampal-Cortical Modelling
https://braincanada.ca/fr/subventions-financées/investigating-spike-timing-dependent-plasticity-mechanisms-of-memory-consolidation-with-multiscale-hippocampal-cortical-modellingThe formation of our memories is a behaviour that encapsulates both long-and-short time scales. Project Overview The formation of our memories is a behaviour that encapsulates both long-and-short time scales. On the short time-scale, memories are initially formed in the hippocampus through the...
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Investigating TDP-43 palmitoylation as a therapeutic target to lower protein aggregation
https://braincanada.ca/fr/subventions-financées/investigating-tdp-43-palmitoylation-as-a-therapeutic-target-to-lower-protein-aggregationTDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Project Overview TDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Although...
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Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS
https://braincanada.ca/fr/subventions-financées/investigating-the-effects-of-c9orf72-haploinsufficiency-on-tdp-43-pathology-in-alsNormal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly. Project Overview Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function...
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Investigating the impact of a ketogenic diet in a mouse model of FUS-ALS
https://braincanada.ca/fr/subventions-financées/investigating-the-impact-of-a-ketogenic-diet-in-a-mouse-model-of-fus-alsAmyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling movement, and many patients also experience major changes in how their bodies use energy. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling...
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Investigating the molecular chaperone DNAJA2 as an inhibitor of tau aggregate pathology in Alzheimer’s
https://braincanada.ca/fr/subventions-financées/investigating-the-molecular-chaperone-dnaja2-as-an-inhibitor-of-tau-aggregate-pathology-in-alzheimer-sAlzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. Project Overview Alzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. One key observation about this...
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Investigating the Neurodevelopmental Trajectory of Emotional Face Processing in Autism Spectrum Disorder
https://braincanada.ca/fr/subventions-financées/investigating-the-neurodevelopmental-trajectory-of-emotional-face-processing-in-autism-spectrum-disorderAn understanding of emotional information from faces is critical for successful social interactions. Project Overview An understanding of emotional information from faces is critical for successful social interactions. A key component of ASD is poor social functioning. Deficits and dysfunction in...
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Investigating the neuronal function of a novel HNRNPA1 variant
https://braincanada.ca/fr/subventions-financées/investigating-the-neuronal-function-of-a-novel-hnrnpa1-variantWhile significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt amyotrophic lateral sclerosis (ALS) progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective...