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In Memoriam - Glenda MacQueen, membre du conseil d'administration de Brain Canada
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/in-memoriam-glenda-macqueen-membre-du-conseil-d-administration-de-brain-canadaLe Conseil d'administration, la direction et le personnel de Brain Canada sont attristés d'apprendre le décès du Dr Glenda MacQueen. Le Dr MacQueen était une championne de la science du cerveau au Canada et a apporté rigueur et perspicacité au Conseil d'administration de Brain Canada. Elle nous...
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In utero exposure to glucocorticoids in humans and an animal model: Epigenetic and transcriptional signatures
https://braincanada.ca/fr/subventions-financées/in-utero-exposure-to-glucocorticoids-in-humans-and-an-animal-model-epigenetic-and-transcriptional-signaturesDr. Sasaki research aims to (1) determine the mechanisms by which maternal synthetic glucocorticoids (sGC) modifies gene networks in a preclinical guinea pig model and (2) determine the mechanism by which a single maternal treatment of sGC modifies gene networks in human cord blood at term...
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In vitro and in vivo functional assessment of neuropsychiatric disease-related synaptic gene mutations
https://braincanada.ca/fr/subventions-financées/in-vitro-and-in-vivo-functional-assessment-of-neuropsychiatric-disease-related-synaptic-gene-mutationsDr. Xie’s research focuses on the functional assessment of neuropsychiatric disease related synaptic genes – MDGA1 and 2. MDGAs bind to critical neuron synaptic proteins – Neuroglin (NLGN), disrupting the binding between NLGN and Neurexin (NRXN), so suppressing synaptogenesis. Project Overview Dr....
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In-vivo CAR-T Therapy for Glioblastoma by Novel Non-Viral Gene Editing System
https://braincanada.ca/fr/subventions-financées/in-vivo-car-t-therapy-for-glioblastoma-by-novel-non-viral-gene-editing-systemCAR-T therapies have delivered promising results for certain hematological cancers but remain largely ineffective for solid tumours with failure nodes including complex and hostile tumor microenvironments and the lack of adapted technological tools. Project Overview Challenge CAR-T therapies have...
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In vivo Quantification of Synaptic Density in Youth With High-risk Cannabis Use: A Positron Emission Tomography Study With the Synaptic Vesicle Glycoprotein 2A Radiotracer [18F]SynVesT-1
https://braincanada.ca/fr/subventions-financées/in-vivo-quantification-of-synaptic-density-in-youth-with-high-risk-cannabis-use-a-positron-emission-tomography-study-with-the-synaptic-vesicle-glycoprotein-2a-radiotracer-18f-synvest-1Frequent heavy use of cannabis is increasingly common in young Canadians. Project Overview Canadian Consortium for the Investigation of Cannabinoids (CCIC) Neuroscience Fellowship in Cannabis and Cannabinoid Research Frequent heavy use of cannabis is increasingly common in young Canadians....
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Incidence, Trends, Determinants, and Prognosis of Post-Stroke Dementia (INTREPID): A 20-year registry and population-based cohort study
https://braincanada.ca/fr/subventions-financées/incidence-trends-determinants-and-prognosis-of-post-stroke-dementia-intrepid-a-20-year-registry-and-population-based-cohort-studyStroke is a common and disabling brain disorder which may have long-lasting effects. Project Overview Stroke is a common and disabling brain disorder which may have long-lasting effects. One of the most feared consequences is the development of cognitive decline and dementia after stroke....
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Inclusive Physical Activity for Kids: KidsAction and Indigenous Dance Programs in Northern BC
https://braincanada.ca/fr/subventions-financées/inclusive-physical-activity-for-kids-kidsaction-and-indigenous-dance-programs-in-northern-bcKidsAction is an evidence-informed coaching approach for children with disabilities. Project Overview KidsAction is an evidence-informed coaching approach for children with disabilities. We co-designed it with families, community groups and Indigenous partners to support children and families in...
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Indices de résilience au stress découverts à la barrière hémato-encéphalique
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/la-résistance-au-stress-et-la-barrière-hémato-encéphaliqueQuels sont les facteurs qui favorisent la résilience au stress? Les chercheurs se sont penchés sur cette question au niveau des neurones pendant des décennies, mais Caroline Ménard a trouvé une réponse là où le système sanguin et le système nerveux interagissent : la barrière hémato-encéphalique...
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Individually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation
https://braincanada.ca/fr/subventions-financées/individually-tailored-prediction-of-treatments-response-in-alzheimer-s-disease-3-clinical-trials-validationLate-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy. Project Overview Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with...
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Inez Jabalpurwala, présidente-directrice générale de Brain Canada, parle de la recherche de traitements pour la maladie d'Alzheimer et la maladie de Parkinson dans le dernier épisode de la baladodiffusion " Saving Minds " de ProMIS Neurosciences.
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/inez-jabalpurwala-président-directeur-général-de-brain-canada-parle-de-la-recherche-de-traitements-pour-la-maladie-d-alzheimer-et-la-maladie-de-parkinson-dans-le-dernier-épisode-du-podcast-promis-neurosciences-saving-mindsÉcouter
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