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In vitro and in vivo functional assessment of neuropsychiatric disease-related synaptic gene mutations
https://braincanada.ca/fr/subventions-financées/in-vitro-and-in-vivo-functional-assessment-of-neuropsychiatric-disease-related-synaptic-gene-mutationsDr. Xie’s research focuses on the functional assessment of neuropsychiatric disease related synaptic genes – MDGA1 and 2. MDGAs bind to critical neuron synaptic proteins – Neuroglin (NLGN), disrupting the binding between NLGN and Neurexin (NRXN), so suppressing synaptogenesis. Project Overview Dr....
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In-vivo CAR-T Therapy for Glioblastoma by Novel Non-Viral Gene Editing System
https://braincanada.ca/fr/subventions-financées/in-vivo-car-t-therapy-for-glioblastoma-by-novel-non-viral-gene-editing-systemCAR-T therapies have delivered promising results for certain hematological cancers but remain largely ineffective for solid tumours with failure nodes including complex and hostile tumor microenvironments and the lack of adapted technological tools. Project Overview Challenge CAR-T therapies have...
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In vivo Quantification of Synaptic Density in Youth With High-risk Cannabis Use: A Positron Emission Tomography Study With the Synaptic Vesicle Glycoprotein 2A Radiotracer [18F]SynVesT-1
https://braincanada.ca/fr/subventions-financées/in-vivo-quantification-of-synaptic-density-in-youth-with-high-risk-cannabis-use-a-positron-emission-tomography-study-with-the-synaptic-vesicle-glycoprotein-2a-radiotracer-18f-synvest-1Frequent heavy use of cannabis is increasingly common in young Canadians. Project Overview Canadian Consortium for the Investigation of Cannabinoids (CCIC) Neuroscience Fellowship in Cannabis and Cannabinoid Research Frequent heavy use of cannabis is increasingly common in young Canadians....
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Incidence, Trends, Determinants, and Prognosis of Post-Stroke Dementia (INTREPID): A 20-year registry and population-based cohort study
https://braincanada.ca/fr/subventions-financées/incidence-trends-determinants-and-prognosis-of-post-stroke-dementia-intrepid-a-20-year-registry-and-population-based-cohort-studyStroke is a common and disabling brain disorder which may have long-lasting effects. Project Overview Stroke is a common and disabling brain disorder which may have long-lasting effects. One of the most feared consequences is the development of cognitive decline and dementia after stroke....
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Inclusive Physical Activity for Kids: KidsAction and Indigenous Dance Programs in Northern BC
https://braincanada.ca/fr/subventions-financées/inclusive-physical-activity-for-kids-kidsaction-and-indigenous-dance-programs-in-northern-bcKidsAction is an evidence-informed coaching approach for children with disabilities. Project Overview KidsAction is an evidence-informed coaching approach for children with disabilities. We co-designed it with families, community groups and Indigenous partners to support children and families in...
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Individually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation
https://braincanada.ca/fr/subventions-financées/individually-tailored-prediction-of-treatments-response-in-alzheimer-s-disease-3-clinical-trials-validationLate-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy. Project Overview Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with...
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Inez Jabalpurwala, présidente-directrice générale de Brain Canada, parle de la recherche de traitements pour la maladie d'Alzheimer et la maladie de Parkinson dans le dernier épisode de la baladodiffusion " Saving Minds " de ProMIS Neurosciences.
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/inez-jabalpurwala-président-directeur-général-de-brain-canada-parle-de-la-recherche-de-traitements-pour-la-maladie-d-alzheimer-et-la-maladie-de-parkinson-dans-le-dernier-épisode-du-podcast-promis-neurosciences-saving-mindsÉcouter
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Inferring computational principles in neural population recordings of evolutionarily-divergent species through artificial intelligence
https://braincanada.ca/fr/subventions-financées/inferring-computational-principles-in-neural-population-recordings-of-evolutionarily-divergent-species-through-artificial-intelligenceNeuroscientists seek to understand how the brain generates cognition and behavior. Project Overview Neuroscientists seek to understand how the brain generates cognition and behavior. A critical piece of this goal is fundamental research in model organisms that provide high degrees of experimental...
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Insulin resistance in the mesolimbic system, a novel hypothesis for depression associated with metabolic resistance from obesity.
https://braincanada.ca/fr/subventions-financées/insulin-resistance-in-the-mesolimbic-system-a-novel-hypothesis-for-depression-associated-with-metabolic-resistance-from-obesityDepression and anxiety are highly prevalent in people with obesity and type 2 diabetes. Project Overview Depression and anxiety are highly prevalent in people with obesity and type 2 diabetes. There are several theories of the cause of this association, however one commonality amongst these...
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Integrated Neurostimulation Platform for Neuropsychiatric Research
https://braincanada.ca/fr/subventions-financées/integrated-neurostimulation-platform-for-neuropsychiatric-researchThe offers the capacity to perform interleaved TMS/fMRI, a complex and demanding technique used to study brain function in neuropsychiatric disorders. Project Overview The offers the capacity to perform interleaved TMS/fMRI, a complex and demanding technique used to study brain function in...
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