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Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences. Project Overview Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences.  Currently, treatment of childhood...

Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by...

Rett syndrome (RTT) is a severe neurological disorder that primarily affects girls, occurring in about 1 in 10,000 births. Project Overview Rett syndrome (RTT) is a severe neurological disorder that primarily affects girls, occurring in about 1 in 10,000 births. Children with RTT experience...

A memory is perhaps the most fragile and personal of all our possessions. Project Overview A memory is perhaps the most fragile and personal of all our possessions. The ability to form and retrieve an episodic memory requires a very complex set of neurobiological processes in the brain. Although...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to...

It is not known why ALS is a rapidly progressing disease. Project Overview It is not known why ALS is a rapidly progressing disease. The discovery that the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) is a pathological hallmark of sporadic ALS and a subset of frontotemporal lobar...

The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Project Overview The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Synapses are plastic and adapt their...

In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. Project Overview In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or...

Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement. Project Overview Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s...

Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression. Project Overview Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression....