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Investigating the role of L-glucose as a therapy and [18F]fluoro-deoxy-L-glucose as a diagnostic for glioblastoma
https://braincanada.ca/fr/subventions-financées/investigating-the-role-of-l-glucose-as-a-therapy-and-18f-fluoro-deoxy-l-glucose-as-a-diagnostic-for-glioblastomaUsing the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of glioblastoma (GBM) as a therapeutic target. Project Overview Using the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of...
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Investigating the role of microglia in brain disorders, by high-throughput single-cell screening of disease-associated genes in human immuno-competent brain avatars
https://braincanada.ca/fr/subventions-financées/investigating-the-role-of-microglia-in-brain-disorders-by-high-throughput-single-cell-screening-of-disease-associated-genes-in-human-immuno-competent-brain-avatarsMost brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem acquired over time, as observed in Alzheimer’s disease. Project Overview Most brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem...
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Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models
https://braincanada.ca/fr/subventions-financées/investigating-the-role-of-mutations-in-chchd10-using-als-cell-and-zebrafish-genetic-modelsCHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Project Overview CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Several dominantly...
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Investigating the role of outer radial glia in autism using human pluripotent stem cells-derived 2D neural cultures and 3D brain organoids
https://braincanada.ca/fr/subventions-financées/investigating-the-role-of-outer-radial-glia-in-autism-using-human-pluripotent-stem-cells-derived-2d-neural-cultures-and-3d-brain-organoidsThe extraordinary size and folded shape of the human brain makes us the smartest animal on earth Project Overview The extraordinary size and folded shape of the human brain makes us the smartest animal on earth. However, it also means many diseases that harm the human brain disrupt cells and...
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Investigating the role of TDP-43 in DNA Replication: Implications for ALS Pathogenesis
https://braincanada.ca/fr/subventions-financées/investigating-the-role-of-tdp-43-in-dna-replication-implications-for-als-pathogenesisCells are constantly under stress due to several environmental and internal factors. Project Overview Cells are constantly under stress due to several environmental and internal factors. Accumulating stress over a period as seen in aging and neurodegenerative diseases like Amyotrophic Lateral...
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Investigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids
https://braincanada.ca/fr/subventions-financées/investigating-the-templated-propagation-and-impact-of-pathogenic-fus-in-hipscs-derived-cerebral-organoidsAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle...
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Investigating the Templated Propagation of the ALS-related Protein FUS in iPSC-derived Cerebral Organoids
https://braincanada.ca/fr/subventions-financées/investigating-the-templated-propagation-of-the-als-related-protein-fus-in-ipsc-derived-cerebral-organoidsAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and paralysis, partly due to the buildup of protein aggregates in nerve cells. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and...
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Investigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models
https://braincanada.ca/fr/subventions-financées/investigating-therapeutic-approaches-for-sptlc1-als-variants-using-zebrafish-modelsWhile most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. Project Overview While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1...
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Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles.
https://braincanada.ca/fr/subventions-financées/investigating-trans-acting-genetic-modifier-variants-association-with-loss-of-interruption-loi-variants-and-impacts-on-age-of-onset-in-relation-to-canonical-allelesHuntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been...
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Investigation of Cerebrovascular Disease across Sexes and Neurodegenerative Disorders through Post-mortem Imaging and Histology
https://braincanada.ca/fr/subventions-financées/investigation-of-cerebrovascular-disease-across-sexes-and-neurodegenerative-disorders-through-post-mortem-imaging-and-histologyOver 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. Project Overview Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over...
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