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Prioritizing Progressive Supranuclear Palsy: a transformative in vivo model of disease pathogenesis with strong translational value for future drug development
https://braincanada.ca/fr/subventions-financées/prioritizing-progressive-supranuclear-palsy-a-transformative-in-vivo-model-of-disease-pathogenesis-with-strong-translational-value-for-future-drug-developmentProgressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. Project Overview Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. By studying the brains of patients who have died scientists have discovered that PSP brains contain toxic deposits...
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Profiling Cortical Excitability in ALS Using Threshold Tracking Transcranial Magnetic Stimulation and Multimodal Biomarkers
https://braincanada.ca/fr/subventions-financées/profiling-cortical-excitability-in-als-using-threshold-tracking-transcranial-magnetic-stimulation-and-multimodal-biomarkersRationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord. Project...
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Project MinE
https://braincanada.ca/fr/subventions-financées/project-mineis a multi-national initiative with currently participating countries. Project Overview is a multi-national initiative with currently participating countries. The goal is to create a database of whole genome sequences for 15,000 people with ALS and 7,500 control subject. This will provide a global...
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Project Overview Retina-based optogenetic therapy is a promising approach to restore vision to individuals suffering from retinal degeneration. After photoreceptor degeneration, optogenetics are targeted to remaining retinal neurons that are not intrinsically light sensitive, in order to make them light-responsive. However, due to technical reasons, the nature of light responses in the retina following optogenetic therapy differ from the light responses in healthy retina. It is unknown how altering retinal light responses via optogenetic therapy changes visual responses in visual cortex, and how this affects visual perception. Here, we will examine visual cortex responses and visual perception in mice following retina-based optogenetic therapy. These results will provide a multiscale analysis providing crucial insights into how the nature of retina-based vision restoration affects its efficacy.
https://braincanada.ca/fr/subventions-financées/project-overview-retina-based-optogenetic-therapy-is-a-promising-approach-to-restore-vision-to-individuals-suffering-from-retinal-degeneration-after-photoreceptor-degeneration-optogenetics-are-targeted-to-remaining-retinal-neurons-that-are-not-intrinsically-light-sensitive-in-order-to-make-them-light-responsive-however-due-to-technical-reasons-the-nature-of-light-responses-in-the-retina-following-optogenetic-therapy-differ-from-the-light-responses-in-healthy-retina-it-is-unknown-how-altering-retinal-light-responses-via-optogenetic-therapy-changes-visual-responses-in-visual-cortex-and-how-this-affects-visual-perception-here-we-will-examine-visual-cortex-responses-and-visual-perception-in-mice-following-retina-based-optogenetic-therapy-these-results-will-provide-a-multiscale-analysis-providing-crucial-insights-into-how-the-nature-of-retina-based-vision-restoration-affects-its-efficacyAnalyzing low-oxygen areas in deadly brain tumours to counter treatment resistance Shreya Gandhi is studying how oxygen-deprived areas of deadly brain tumours called glioblastoma (GBM) contribute to treatment resistance to improve treatment options and outcomes for people with this type of cancer....
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Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration
https://braincanada.ca/fr/subventions-financées/propagated-protein-misfolding-of-sod1-in-als-exemplar-for-neurodegenerationAmyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons). Project Overview Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal...
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Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells
https://braincanada.ca/fr/subventions-financées/proteomic-and-transcriptomic-profiling-of-paraspeckle-function-in-healthy-and-als-model-neuronal-cellsOver the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably. Project Overview Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded...
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Proteomic associations with brain and cognitive health and their interactions with modifiable risk factors for dementia
https://braincanada.ca/fr/subventions-financées/proteomic-associations-with-brain-and-cognitive-health-and-their-interactions-with-modifiable-risk-factors-for-dementiaAs people live longer, our society undergoes rapid demographic change. Project Overview As people live longer, our society undergoes rapid demographic change. Dementia and cognitive impairment in older adults poses a greater challenge to our healthcare system, affecting patients and caregivers....
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Prototype NIR Ca2+ indicators into refined tools that can be applied for neuronal activity imaging in model organisms
https://braincanada.ca/fr/subventions-financées/prototype-nir-ca2-indicators-into-refined-tools-that-can-be-applied-for-neuronal-activity-imaging-in-model-organismsOne of the major challenges facing the BRAIN initiative is the development of technologies that will enable the recording of neural activity throughout the entire volume of a rodent brain. Project Overview One of the major challenges facing the BRAIN initiative is the development of technologies...
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Présentation des bénéficiaires des subventions 2025 du programme de recherche de la Société Alzheimer
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/présentation-des-boursiers-2025-du-programme-de-recherche-de-la-société-alzheimerBrain Canada, en partenariat avec la Société Alzheimer du Canada, est fier d'annoncer les 2025 récipiendaires de subventions du Programme de recherche de la Société Alzheimer (PRSA) ! Ces chercheurs sont à l'avant-garde de la recherche sur la maladie d'Alzheimer et les démences apparentées et...
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Psychological health and wellness among medical doctors in Canada and the impact of the Wellness4MDs supportive text messaging program.
https://braincanada.ca/fr/subventions-financées/psychological-health-and-wellness-among-medical-doctors-in-canada-and-the-impact-of-the-wellness4mds-supportive-text-messaging-programThis project’s main aim is to create and test a daily text messaging program called Wellness4MDs to help doctors, medical trainees, and students in Canada deal with burnout, anxiety, and depression. Project Overview This project’s main aim is to create and test a daily text messaging program called...
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