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Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons
https://braincanada.ca/fr/subventions-financées/pre-clinical-drug-discovery-against-hexanucleotide-repeat-containing-c9orf72-toxicity-using-caenorhabditis-elegans-and-patient-derived-induced-motor-neuronsA few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis. Project Overview A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor...
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Precision diagnosis and prognosis of primary and metastatic brain tumours using DNA methylation profiling in liquid biopsy
https://braincanada.ca/fr/subventions-financées/precision-diagnosis-and-prognosis-of-primary-and-metastatic-brain-tumours-using-dna-methylation-profiling-in-liquid-biopsyNeed for project: More sensitive molecular tools are needed in the field of neuro-oncology to enable early detection, more accurate diagnosis, and prediction of outcome for brain tumors. Project Overview Need for project: More sensitive molecular tools are needed in the field of neuro-oncology to...
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Precision in Space and Time: Brain State-Dependent Stimulation Using Real-Time EEG and TMS
https://braincanada.ca/fr/subventions-financées/precision-in-space-and-time-brain-state-dependent-stimulation-using-real-time-eeg-and-tmsThe goal of this project is to develop new principles to treat brain disease and investigate brain function using non-invasive neurostimulation, without the side-effects of drugs. Project Overview The goal of this project is to develop new principles to treat brain disease and investigate brain...
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Precision Metabolism: Deciphering and Targeting Metabolic Adaptations in Therapy-Resistant Recurrent Glioblastoma
https://braincanada.ca/fr/subventions-financées/precision-metabolism-deciphering-and-targeting-metabolic-adaptations-in-therapy-resistant-recurrent-glioblastomaGlioblastoma (GBM) is a common and deadly brain cancer in adults. Project Overview Glioblastoma (GBM) is a common and deadly brain cancer in adults. Doctors use strong medicine (chemotherapy) and special rays (radiation therapy) to treat it. However, 80-90% of patients see the cancer come back, and...
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Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers
https://braincanada.ca/fr/subventions-financées/preclinical-and-clinical-studies-with-withanolides-therapeutic-effects-molecular-signatures-and-biomarkersOne of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA–binding protein 43 (TDP-43). Project Overview One of the hallmarks of ALS is the presence of abnormal clumps inside...
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Preclinical development of a disease modifying small molecule therapy for Alzheimer disease
https://braincanada.ca/fr/subventions-financées/preclinical-development-of-a-disease-modifying-small-molecule-therapy-for-alzheimer-diseaseNo medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Project Overview No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches...
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Predicting Behavioural Deficits and Creating Biomarkers After Repeated Sub-concussive Injury
https://braincanada.ca/fr/subventions-financées/predicting-behavioural-deficits-and-creating-biomarkers-after-repeated-sub-concussive-injuryConcussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Project Overview Concussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Sub-concussive injuries,...
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Prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure on brain development, cognition and activity related risk for obesity: A longitudinal study with 10 year olds
https://braincanada.ca/fr/subventions-financées/prenatal-serotonin-reuptake-inhibitor-sri-antidepressant-exposure-on-brain-development-cognition-and-activity-related-risk-for-obesity-a-longitudinal-study-with-10-year-oldsDr. Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. Project Overview Dr. Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. her current...
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Preventing Language Decline in Dementia
https://braincanada.ca/fr/subventions-financées/preventing-language-decline-in-dementiaPrimary progressive aphasia (PPA) is a form of dementia which impairs the ability to understand spoken and written language but other cognitive skills (including memory) remain intact for several years after its onset. Project Overview Primary progressive aphasia (PPA) is a form of dementia which...
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Prevention of Alzheimer’s Dementia in High Risk Populations: A Randomized Controlled Trial of a Combination of Cognitive Remediation and Brain Stimulation
https://braincanada.ca/fr/subventions-financées/prevention-of-alzheimer-s-dementia-in-high-risk-populations-a-randomized-controlled-trial-of-a-combination-of-cognitive-remediation-and-brain-stimulationThis project is studying a novel intervention in 250 older persons whose major depression has been successfully treated with an antidepressant medication: a combination of cognitive remediation (CR, consisting of memory and problem solving exercises) plus transcranial Direct Current Stimulation...
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