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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and paralysis, partly due to the buildup of protein aggregates in nerve cells. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and...

While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. Project Overview While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1...

Huntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been...

Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. Project Overview Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over...

Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. Project Overview Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. The disorder almost exclusively affects females, presents in childhood and...

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Project Overview Scientists have long wondered what the contribution of environment is to ALS and in...

The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Project Overview The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD),...

In recent years, it was discovered that a microscopic worm called C. elegans could mimic some of the aspects of human ALS when they were engineered to have abnormal (mutant) genes that cause the disease. Project Overview In recent years, it was discovered that a microscopic worm called C. elegans...

Le programme Bourses pour étudiants de premier cycle 2026 a pour objectif d’attirer les jeunes scientifiques les plus brillants vers la recherche sur la maladie de Huntington et de favoriser la conduite de travaux pertinents visant à comprendre les mécanismes biologiques sous-jacents à la pathologie...

La Foundation Brain Canada et Diabète Canada sont heureux d’annoncer le financement de deux projets de recherche à la croisée du diabète et de la santé mentale. Ensemble, Brain Canada et Diabète Canada octroieront et cofinanceront deux subventions de 450 000 dollars chacune sur trois ans dans le...