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The Regeneration Unit in Neurobiology (RUN) Core facility is a purpose-built centre specializing in state of the art microscopic imaging of cells and tissue, as well as sophisticated behavioural analysis of laboratory rodents. Project Overview The Regeneration Unit in Neurobiology (RUN) Core...

Dr. Peter McPherson, professor at the Montreal Neurological Institute, McGill University will receive one year of support to work on the connection between the most prominent known cause of ALS, a mutation in a gene called C9ORF72, and a previously unrelated critical cellular function called...

When cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in. Project Overview When cells are under stress, one of the reactions is to form tiny clumps called stress granules that...

The human experience is marked by constant learning. Project Overview The human experience is marked by constant learning. Moments of contention, when new experiences conflict with prior knowledge, often lead to the most meaningful learning. How do we successfully navigate these moments and gain...

“Dementia is now recognised as a terminal illness and a leading cause of death globally. People living with dementia (PLwD) in Canada suffer painful, undignified, and inhumane end-of-life (EOL) experiences. Project Overview “Dementia is now recognised as a terminal illness and a leading cause of...

Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. Project Overview Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective...

In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). Project Overview In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). MS treatments stop...

RATIONALE: There are no effective disease modifying therapies for amyotrophic lateral sclerosis (ALS). Project Overview RATIONALE: There are no effective disease modifying therapies for amyotrophic lateral sclerosis (ALS). Complete understanding of the physiopathology of ALS is lacking, and...

The loss of connections between nerve cells is an early indicator of Alzheimer’s disease. Project Overview The loss of connections between nerve cells is an early indicator of Alzheimer’s disease. The loss of these connections also causes difficulty thinking and processing information....

Our ability to learn is directly proportional to our ability to detect the difference between a prediction and its outcome. Project Overview Our ability to learn is directly proportional to our ability to detect the difference between a prediction and its outcome. Reinforcement learning theories,...