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Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Project Overview Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Current treatment includes surgical resection, chemotherapy, and radiation. However, since GBM is...

Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major challenge to society, both from a financial and social perspective. Project Overview Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major...

The brain is isolated from the peripheral blood circulation by a barrier (ie the blood-brain barrier) that protects it from the entrance of harmful substances (pathogenic or inflammatory agents) and prevents excessive fluctuations in the levels of circulating molecules. Project Overview The brain...

Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Project Overview Metabolic syndrome is a group of risk factors (obesity, hypertension, high...

Periodontal disease has links with Alzheimer’s disease. Project Overview Periodontal disease has links with Alzheimer’s disease. The bacterium Porphyromonas gingivalis plays a major role in gum disease and has been associated with Alzheimer’s disease. We have identified a small protein, produced by...

A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Project Overview A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the...

Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD) are devastating diseases in which a protein called TDP-43 ends up in the wrong part of the cell, disrupting its normal role in managing RNA. Project Overview Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD)...

Glioblastoma multiforme (GBM) the most common form of brain cancer in adults with very low survival of only 15 months with less than 5% of patients surviving more than 5 years. Surgery, chemotherapy, and radiation are the treatments currently used but recurrence is very common, often with tumors...

Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Project Overview Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory...

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. Project Overview Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. However, even for genetically defined components of...