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This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction. Project Overview This project will focus on comprehensively studying impaired transmission of signals (from the...

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to...

Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. Project Overview Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to...

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Project Overview This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on...

In Canada, one individual suffers a stroke every seven minutes. Project Overview In Canada, one individual suffers a stroke every seven minutes. Of those who survive, roughly 30% will have aphasia, a difficulty speaking with- or understanding others. Aphasia can have a significant negative impact...

Our research program is centered on investigating the important contributions of metabolism to brain health. Project Overview Our research program is centered on investigating the important contributions of metabolism to brain health. It is generally well-accepted that proper nutrition is a major...

Brain Canada est attentif à l'impact du COVID-19 sur la communauté des chercheurs. La pandémie actuelle renforce la nécessité d'une information solide, rigoureuse et fondée sur des faits, et d'un soutien à la communauté scientifique. Brain Canada a mis en place un plan de continuité des activités...

Apathy (reduced goal-directed behaviour) is common in persons with dementia and is associated with lower quality of life, increased dependence and faster decline. Project Overview Apathy (reduced goal-directed behaviour) is common in persons with dementia and is associated with lower quality of...

Despite the recent advances in our understanding between the connection between the microbes living in the gut and our mental health, there remains a wide knowledge gap in understanding how the brain is negatively impacted in disorders with inflammation of the gut. Project Overview Despite the...