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836 résultats trouvés

Restoring Hippocampal Disinhibition to Reverse Early Memory Deficits in Alzheimer’s Disease

Alzheimer’s disease can affect memory and thinking by changing how brain cells communicate. Our project looks at early changes in the hippocampus, a part of the brain important for learning and memory.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
Alzheimer Society Research Program (ASRP) 2025-2026
Province
Québec
DATE DE DÉBUT
2026

Restoring Cerebrovascular Health in Alzheimer’s Disease by Targeting Molecular Damage in the Neurovascular Unit

Alzheimer’s disease is linked to the build-up of harmful proteins in the brain and damage to brain blood vessels. In many people, especially in later life, this build-up happens because the brain cannot clear these proteins effectively. Our research focuses on understanding how aging damages the blood vessels in the brain and reduces this natural cleaning process.

TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
Alzheimer Society Research Program (ASRP) 2025-2026
Province
Ontario
DATE DE DÉBUT
2026

The influence of loss of interruption variants on astrocyte reactivity in Huntington disease

The Huntington disease (HD) mutation produces a pathogenic mutant HTT (mHTT) protein with an elongated polyglutamine tract. Presence of mHTT disrupts diverse cellular pathways, leading to adverse molecular phenotypes including inflammation, impaired synaptic transmission, and eventually neurodegeneration. Although HD has a singular genetic cause, there have been recent advances in our understanding of HD gene modifiers (PMID: 26232222).

TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
Colombie-Britannique
DATE DE DÉBUT
2026

Beyond Exon 1: Exploring the Pathogenic Role of Novel Huntingtin Aggregates in vivo.

Mutations within exon 1 of the huntingtin (HTT) protein promote its aggregation and accumulation in the brain and periphery, ultimately driving neuronal dysfunction and the clinical manifestation of Huntington’s disease (HD). Although HTT is a large protein composed of more than 3,000 amino acids, exon 1 represents less than 3% of its total length. For decades, this small N-terminal fragment has been viewed as the principal driver of pathology. Yet HTT is far more than exon 1, and regions outside this domain can also undergo proteolytic processing, potentially generating toxic species whose contribution to disease remains poorly understood.

TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
Québec
DATE DE DÉBUT
2026

Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles.

Huntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been identified through genome-wide association studies (GWAS) that alter the onset and severity of disease to varying degrees.

TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
Colombie-Britannique
DATE DE DÉBUT
2026

Brain network-based determination of genes that clear mutant huntingtin fibrils

Huntington disease (HD) is caused by a CAG trinucleotide repeat expansion within the huntingtin (HTT) gene which produces a mutant HTT (mHTT) protein. This mHTT protein aggregates within neurons, forming fibrils that interfere with cellular functions and result in neurodegeneration. The spatiotemporal dynamics of HD pathogenesis is a complex interplay between mHTT production, spread, and likely clearance: fibrils spread from cell-to-cell in prion-like and concentration-dependent manners, and initial seeding of fibrils is preferentially seen in certain cell types (striatal medium spiny neurons). Furthermore, evidence from other disorders (Parkinson's) indicate the presence of neuroprotective genes (e.g. GBA) that clear pathogenic proteins. In HD, clearance genes remain an area of active investigation.

TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
Alberta
DATE DE DÉBUT
2026

Enabling Neuroscience research Approaches for Brain, feeLings and Emotions (ENABLE): An Innovative Platform for Clinical Trials in Mood Disorders

Depression and bipolar disorder, known as mood disorders, significantly impact the lives of many Canadians, especially women and the LGBTQ+ community. Although many treatments are available, it is often challenging for clinicians to determine which treatment is the right one for a particular individual.


TYPE DE SUBVENTION
Subventions de plateforme
Domaine de recherche
Santé mentale
Province
Ontario
DATE DE DÉBUT
2026

WONDER: A Data Platform for AI-Enabled Precision Health in Childhood Disability

Brain-based disabilities, such as autism, ADHD, cerebral palsy, and rare genetic conditions, affect one in five children and often lead to lifelong challenges. These conditions are complex and vary widely from child to child, making it difficult to find treatments that work for everyone. Despite years of research, we still lack the tools to understand this diversity and provide personalized care. To address this, we propose WONDER (Whole-Child Open Neuroscience Data for Empowering Research), a new national research platform that will securely connect and analyze data from across Canada.


TYPE DE SUBVENTION
Subventions de plateforme
Domaine de recherche
Développement neurologique
Province
Ontario
DATE DE DÉBUT
2026

Centre for Neurotechnological Innovation to Application

The Centre for Neurotechnological Innovation to Application (CRANIA) transforms routine neurosurgical procedures into valuable research opportunities to advance brain science and treatment. Currently, when patients undergo procedures like deep brain stimulation for Parkinson's disease or surgery for epilepsy, the unique brain data captured during these interventions often remains isolated in specialized hospitals, limiting scientific discovery.


TYPE DE SUBVENTION
Subventions de plateforme
Domaine de recherche
Neurotechnologie
Province
Ontario
DATE DE DÉBUT
2026

CFMM: Canada's National Ultra-High Field MRI Platform

Magnetic Resonance Imaging (MRI) is well known for its essential diagnostic role in modern medicine, but it is also an invaluable tool in studying the structure, function and metabolism of the brain for fundamental research and clinical translation.


TYPE DE SUBVENTION
Subventions de plateforme
Domaine de recherche
Neurotechnologie
Province
Ontario
DATE DE DÉBUT
2026