Subventions financées

Amyotrophic lateral sclerosis (known as ALS or Lou Gehrig’s disease) is a debilitating disease that causes loss of control over muscles and leads to death quickly after diagnosis.

Depression and anxiety are highly prevalent in people with obesity and type 2 diabetes.

What is the role of apolipoprotein receptor 2, a protein found in the brain vessels, in Alzheimer’s disease ?

We identified changes in the gene called IRF2BPL (Interferon Regulatory Factor 2 Binding Protein Like) as the cause of a severe brain disorder in children called NEDAMSS (Neurodevelopmental disorder with abnormal movements, loss of speech and seizures).

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD).

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death.

Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction.

Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells.

Mutations in the metabolic enzymes are commonly observed in brain cancers.