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A pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub)

Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD).

The loss of connections between nerve cells is an early indicator of Alzheimer’s disease.

Anne-Sophie Sack, a doctoral candiate at the University of British Columbia

Most strokes occur from clots blocking vessels that supply blood flow to the brain.

Stroke happens to 62,000 people each year in Canada.

The main aim of this project is to examine the efficacy of the non-pharmacological intervention of lower body negative pressure (LBNP) with head up tilt on cerebral blood flow and concussion symptoms during exercise in individuals with persisting symptoms.

Microglia, the brain’s resident immune cells, are vital for healthy brain function.

RATIONALE: There are no effective disease modifying therapies for amyotrophic lateral sclerosis (ALS).

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient.