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Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles.

Huntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been identified through genome-wide association studies (GWAS) that alter the onset and severity of disease to varying degrees.
Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
British Columbia
Start Date
2026