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Validation of clinical assays to measure GCase activity in white blood cells for identifying GBA1-associated Parkinson’s Disease
https://braincanada.ca/funded-grants/validation-of-clinical-assays-to-measure-gcase-activity-in-white-blood-cells-for-identifying-gba1-associated-parkinson-s-diseaseEnzymes are mother nature’s catalysts responsible for the chemistry of metabolic pathways in living cells. In some diseases, the function of an enzyme is deficient which can lead to dysfunction or early cell death. Project Overview Enzymes are mother nature’s catalysts responsible for the chemistry...
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Validation of cognitive rehabilitation program adapted to the needs of adults with brain cancer and adult survivors of childhood brain cancer.
https://braincanada.ca/funded-grants/validation-of-cognitive-rehabilitation-program-adapted-to-the-needs-of-adults-with-brain-cancer-and-adult-survivors-of-childhood-brain-cancerWe propose a randomized controlled trial to evaluate the efficacy of Goal Management Training (GMT) for improving these patients’ cognitive functioning as well as patient and caregiver QoL. Project Overview We propose a randomized controlled trial to evaluate the efficacy of Goal Management...
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Validation of Connexins and Pannexins as a target for Alzheimer’s Disease
https://braincanada.ca/funded-grants/validation-of-connexins-and-pannexins-as-a-target-for-alzheimer-s-diseaseAlzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. Project Overview Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As...
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Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration
https://braincanada.ca/funded-grants/validation-of-ocular-measures-as-potential-biomarkers-for-early-detection-of-brain-amyloid-and-neurodegeneration500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. Project Overview 500,000 Canadians have dementia, a number that will...
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Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis
https://braincanada.ca/funded-grants/validation-of-small-molecules-preventing-tdp-43-aggregation-as-a-therapeutic-for-amyotrophic-lateral-sclerosisTDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. Project Overview TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped...
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Vascular innervation and blood-brain barrier dysfunction in Huntington’s disease using human iPSC-derived vascularized brain organoids.
https://braincanada.ca/funded-grants/vascular-innervation-and-blood-brain-barrier-dysfunction-in-huntington-s-disease-using-human-ipsc-derived-vascularized-brain-organoids“Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been documented in Huntington’s disease (HD). Project Overview “Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been...
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Vascular Interface with the Brain and Neurocognition via the Eyes (VIBE): Retinal Photography in Youth with Psychiatric Disorders
https://braincanada.ca/funded-grants/vascular-interface-with-the-brain-and-neurocognition-via-the-eyes-vibe-retinal-photography-in-youth-with-psychiatric-disordersThe goal of this study is to advance knowledge regarding the association of vascular risk factors and blood vessels with brain structure and function in youth with severe mental illness. Project Overview The goal of this study is to advance knowledge regarding the association of vascular risk...
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Verifying aerobic training protocols to benefit both heart and brain in subacute stroke
https://braincanada.ca/funded-grants/verifying-aerobic-training-protocols-to-benefit-both-heart-and-brain-in-subacute-strokeBecause of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Project Overview Because of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Exercise...
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Volunteer Linda Auger Morissette’s annual fundraising walk in Saint-Basile-de-Portneuf raises more than $10,000 for ALS research
https://braincanada.ca/about/news-updates/volunteer-linda-auger-morissette-s-annual-fundraising-walk-in-saint-basile-de-portneuf-raises-more-than-10-000-for-als-researchMonica Berger, Brain Canada's National Director of Philanthropy (left), along with Linda Auger Morissette (right), the leader of The Perseids of Hope annual walk to support ALS research. In 2017, Linda Auger Morissette’s brother, Pierre, received an amyotrophic lateral sclerosis (ALS) diagnosis at...
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Walking into a Virtual World: A Pilot Randomized Trial using Virtual Reality and Omnidirectional Treadmill Training for People with Chronic Stroke
https://braincanada.ca/funded-grants/walking-into-a-virtual-world-a-pilot-randomized-trial-using-virtual-reality-and-omnidirectional-treadmill-training-for-people-with-chronic-strokeCognitive function (thinking, memory, and concentration), balance, and walking problems affect the lives of many stroke survivors. Project Overview Cognitive function (thinking, memory, and concentration), balance, and walking problems affect the lives of many stroke survivors. Virtual reality (VR)...
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