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774 results found

Novel Repetitive Transcranial Magnetic Stimulation Paradigm to Reduce Cortical Hyperexcitability in Patients with ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

ALS is a devastating neurological disease characterized by the progressive degeneration of motor neurons leading to paralysis and death. Although the exact cause of ALS remains unknown in the majority of patients, abnormalities in the motor cortex of the brain can be detected early in the disease and may be…

Project Ongoing

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A multi-methods multi-site study of end-of-life care in individuals with ALS: goal concordance and caregiver perceptions

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Amyotrophic lateral sclerosis (ALS) is a terminal disease of nerves and muscles. From the time of symptom onset, people with ALS live about 3-5 years. Death results in significant grief in their caregivers. Previous research has shown where people with ALS are dying, but none have shown where they want…

Project Ongoing

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Exploring a therapeutic approach to promote neuronal function for ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases which have overlap in pathological features and the genetic basis. We recently discovered that treating mouse neurons Analysis of neurons isolated from mice which carry a genetic alteration associated with human ALS/FTD, revealed a variety of defects…

Project Ongoing

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Selection of DNA Aptamers for Inhibition of Protein Aggregation in ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $120,000

  • Health Canada Contribution

    $60,000

Project Overview

The fight against ALS is made extremely challenging due to its largely unknown origin in most patients. This is the case for sporadic ALS, which accounts for up to 90% of all ALS cases, leaving this cohort of patients searching for answers. Our proposal aims to tackle one of the…

Project Ongoing

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Stress granules: neuroprotective or neurotoxic in ALS pathogenesis?

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2025

  • Total Grant Amount

    $300,000

  • Health Canada Contribution

    $150,000

Project Overview

ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones. With the exception of SOD1 families, despite decades of research, we have yet to identify a truly disease-modifying therapy for ALS. We believe that this is due not…

Project Ongoing

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