720 results found
Examining vascular risk and menopausal age on women’s increased risk for AD
Project Overview
Two-thirds of individuals suffering from Alzheimer’s disease are women. The reason for women’s increased risk of Alzheimer's disease is unknown. Menopause occurs when a decline in a hormone called estrogen causes middle-aged women to stop having menstrual periods. Early menopause can increase the risk of Alzheimer's disease. Vascular conditions, such…
Project Ongoing
See the project and researchersTargeting KCC2 for rescuing functional impairments in Alzheimer’s disease
Project Overview
Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory signals is vital for the brain to function. Many components maintain this balance, but one key player is the protein KCC2. As levels of KCC2 are…
Project Ongoing
See the project and researchersSelf-disclosure about dementia on social media: evidence-informed guidance
Project Overview
Individuals who engage on social media often disclose a personal dementia diagnosis or identify as a caregiver, yet little is known about the impact of that disclosure. The goal of this project is to address this gap and develop a resource to support users to navigate social media. We will…
Project Ongoing
See the project and researchersA Drug Screening Assay to Reduce LINGO-1 Amounts in Neurons
Project Overview
The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and myelination. LINGO-1 inhibition increases survival of multiple neural types and improves spatial learning, memory, and cognitive abilities in multiple mouse models. Thus, we hypothesize…
Project Ongoing
See the project and researchersCognitive training platform to revolutionize healthcare for people with concussions
Project Overview
Led by Dr. Jocelyn Faubert from the Université de Montréal in collaboration with Neurotracker Athletics Inc., this project includes an inter-provincial research collaboration with Prof. Brian Christie and Prof. Jodie Gawryluk from the University of Victoria. Awarded through the CQDM-Brain Canada Joint Call for Collaborative Research Projects on the Brain…