720 results found
A novel immunotherapy based on genetically modified hematopoietic stem cells as a new hope for treating glioblastoma, an aggressive cancerous tumor of the brain
Project Overview
Led by Dr. Elie Haddad from CHU Sainte-Justine in collaboration with Immugenia, this project includes an inter-provincial research collaboration with Prof. Scott McComb and Prof. Anna Jezierski of the National Research Council of Canada (NRC) and the University of Ottawa who are advancing research innovations through the NRC’s Disruptive Technology…
Project Ongoing
See the project and researchersThe application of 3D models to assess the role of microglia in neurodegenerative disorders
Project Overview
Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction. While microglia, the immune cells resident in the central nervous system,…
Project Ongoing
See the project and researchersPrecision Metabolism: Deciphering and Targeting Metabolic Adaptations in Therapy-Resistant Recurrent Glioblastoma
Project Overview
Glioblastoma (GBM) is a common and deadly brain cancer in adults. Doctors use strong medicine (chemotherapy) and special rays (radiation therapy) to treat it. However, 80-90% of patients see the cancer come back, and the usual treatments don't work anymore. This project aims to find out why GBM comes back…
Project Ongoing
See the project and researchersTargeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas
Project Overview
The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells in cancer, we can understand how they promote tumor progression. In this project, our goal is to modify the activity of a…
Project Ongoing
See the project and researchersImpact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence
Project Overview
Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in metabolic pathways confer altered metabolic function by increasing production of the oncogenic metabolite R-2-Hydroxyglutarate (R-2HG). This metabolite was shown to promote…