720 results found
Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells
Project Overview
Developmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC). Among these pathways, Hippo and Wnt signal transduction are implicated in the growth of glioma…
Project Complete
See the project and researchersNonlinear MR-US Registration for Image Guided Neurosurgery of Brain Tumours
Project Overview
The broad aim of this project is to develop and evaluate nonlinear registration techniques that account for discontinuities in data from tissue resection in order to accurately reflect the deformed brain. These registration procedures will improve patient-image alignment during surgery and enable correction of preoperative data to reflect the intraoperative…
Project Complete
See the project and researchersIdentification of Brain Metastasis Initiating Cells and Regulators of Brain Metastasis from Lung Cancer
Project Overview
A recent study by the Massague group has identified genes that mediated breast cancer metastasis to the brain by using genomic expression analysis to compare in vivo-selected brain metastasis cell lines to the corresponding parental lines. Knockdown of these genes reduced the migration and invasiveness of BM-derived cells in vitro…
Project Complete
See the project and researchersDrug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches
Project Overview
Although it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated. Specifically, it remains unknown whether miRNAs and LncRNAs, have other…
Project Complete
See the project and researchersSeason, Light Exposure and Serotonin Transporter Binding
Project Overview
The serotonin transporter (5-HTT) is a protein that clears extracellular serotonin from the synapses and depletion of serotonin is associated with depressive symptoms. Previously, in healthy individuals, we discovered that 5-HTT BPNo, an index of 5-HTT levels, was greater in affect-modulating brain regions in the fall/winter compared to the spring/summer;…