Directory of funded grants

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587 results found

Montreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants

  • Grant Type

    Team grants

  • Area of research

    Multiple

  • Disease Area

    Autism,  Mental illness

  • Competition

    2015 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ. This suggests that many different mechanisms are causing these disorders in patients. This great diversity has hindered…

Project Ongoing

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Preclinical development of a disease modifying small molecule therapy for Alzheimer disease

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $1,410,000

  • Health Canada Contribution

    $705,000

Project Overview

No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches need to be quickly pursued in order to develop useful treatments for the aging population. The two pathological hallmarks of AD are protein…

Project Complete

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Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,410,000

  • Health Canada Contribution

    $705,000

Project Overview

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today,…

Project Complete

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Modulating memory circuits: focal DBS treatments to improve medial temporal lobe function

  • Grant Type

    Team grants

  • Area of research

    Multiple

  • Disease Area

    Alzheimer’s,  Epilepsy

  • Competition

    2014 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $1,387,295

  • Health Canada Contribution

    $693,647

Project Overview

Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The diseases in question are Alzheimer’s disease, a devastating neurodegenerative disorder, and temporal lobe epilepsy, the most common type of partial-seizure epilepsy, characterized by brief episodes of abnormally synchronous neural activity.…

Project Complete

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Biomarkers for Crossing the Translational Divide in Acute Spinal Cord Injury

  • Grant Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Brain Injury

  • Competition

    2014 MIRI Team Grants

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $2,775,000

  • Health Canada Contribution

    $1,387,500

Project Overview

Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Unfortunately, none of the promising treatments that have emerged from animal models of SCI have demonstrated convincing neurologic…

Project Complete

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