720 results found
Multi-modal neuroimaging biomarkers of Parkinson’s disease progression
Project Overview
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world. PD can manifest and develop in a variety of ways for different patients, and it is currently not possible to reliably determine, for a given patient, which subtype of PD they have and what course their…
Project Ongoing
See the project and researchersThe effects of different types of exercise on sleep quality and architecture in people with Parkinson’s disease
Project Overview
Most people with Parkinson's Disease (PD) suffer from sleep problems and show marked alterations in sleep architecture (i.e., the basic structural organization of normal sleep). These alterations are clinically relevant because they increase the risk of developing age-related cognitive problems and dementia and can accelerate the motor deterioration of the…
Project Ongoing
See the project and researchersTACAN regulates mesenchymal versus amoeboid cell states in glioblastoma
Project Overview
Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Current treatment includes surgical resection, chemotherapy, and radiation. However, since GBM is fastgrowing and highly invasive, existing therapies often result in tumour recurrence and poor survival outcomes, emphasizing the importance of the development of novel therapeutic targets.…
Project Ongoing
See the project and researchersNeuro-immunity in glioma and melanoma brain metastasis
Project Overview
Melanoma brain metastases (MBMs) are a serious issue affecting up to half of all patients with stage IV melanoma, typically leading to a poor outlook. While immune therapy using anti-PD-1 can help, it only works for about 20% of MBM patients, which is much lower than the response seen in…
Project Ongoing
See the project and researchersEnhancing Therapeutic Responses to IDH Inhibitors in IDH Mutated Gliomas
Project Overview
Gliomas are a type of brain tumor that pose a significant health concern due to their severity. Some of these tumors have alterations, known as mutations, in genes called IDH1 or IDH2 which affect how the tumor behaves and grows. Vorasidenib is a promising new medicine that is being studied…