720 results found
Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma
Project Overview
We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour's molecular makeup and found three subtypes with different survival rates. One subtype, called "Ciliary," stands out because of…
Project Ongoing
See the project and researchersIdentification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging
Project Overview
People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These symptoms can have a significant impact on their risk of suicide, prognosis, and overall quality of life. The fact that depressive and negative symptoms in schizophrenia have a lot in common…
Project Ongoing
See the project and researchersBrain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation
Project Overview
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD). rTMS applies a series of pulses to the prefrontal cortex, leading to changes…
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See the project and researchersDefective protein translation: a causative pathway in ALS
Project Overview
Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. ALS causes motor neurons to deteriorate and die, leading to muscle control loss. ALS patients lose control of the muscles needed to move, speak, eat, and breathe,…
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See the project and researchersCharacterizing the effects of blocking TDP-43 SUMOylation during cellular stress and recovery using live-cell imaging
Project Overview
A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called "SUMOylation" that helps prevent the clumping of TDP-43. We created a mouse model where we disrupted SUMOylation and observed that these…