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The effects of intensity and volume of physical activity on cerebrovascular health in women across the menopausal transition
Project Overview
Our research project will investigate the relationship between physical activity and brain vascular health in women. The term vascular brain health refers to the health of blood vessels within the brain. To measure brain vascular health, we use cerebrovascular reactivity (CVR) which quantifies the abilities of blood vessels to expand…
Project Ongoing
See the project and researchersMolecular processes underlying neuromuscular junction denervation in humans with ALS
Project Overview
Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). This can be one of the earliest pathological processes observed in ALS. Past investigations demonstrated NMJ dysfunction and a period of denervation-reinnervation cycling occurs before motor neuron loss. Additionally, some evidence suggests the rescue of motor…
Project Ongoing
See the project and researchersRoutine enfant TDAH Phase 2
Project Overview
“La bonne intervention, au bon moment, pour le bon enfant”. Le bien-être et l’amélioration des capacités adaptatives des enfants ayant des troubles du neurodéveloppement nécessitent des interventions personnalisées dans le temps, l’intensité, les modalités, Malheureusement, bien que ce principe soit très largement reconnu, la réalité des enfants et de leur…
Project Ongoing
See the project and researchersFunctional connectivity-guided rTMS for personalized treatment of apathy
Project Overview
Nearly half the people affected with Alzheimer’s disease will at some point show reduced motivation to perform their daily activities or participate in activities they previously enjoyed. They may also show fewer emotions or self-initiative in their daily lives. Such a reduction in behavior is termed as apathy and affects…
Project Ongoing
See the project and researchersDynamic interplay of vascular injury and inflammation on AD progression
Project Overview
Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied to the brain. Such vascular damage can increase the risk of Alzheimer's disease (AD) by up to three times. The brain has specialized immune cells, called astrocytes and microglia,…