Directory of funded grants

Filter by

552 results found

Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $195,000

  • Health Canada Contribution

    $97,500

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the…

Project Complete

See the project and researchers

Regulation of the stress granule proteome and transcriptome by TDP-43 in ALS: biomarkers and therapeutic targets

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $1,685,750

  • Health Canada Contribution

    $842,875

Project Overview

When cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in. Toxicity in ALS might arise from both an abnormal ability to properly form stress granules and/or a failure to disassemble stress granules after…

Project Ongoing

See the project and researchers

Discovery of Therapeutic Targets for FUS- and TDP43-Dependent Forms of ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $1,382,685

  • Health Canada Contribution

    $691,342

Project Overview

The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72. Of these, TDP-43 and FUS have the most in common. Not only do they share similar functions inside cells, but in motor neurons of people with ALS, they both accumulate in clumps outside of the area where…

Project Complete

See the project and researchers

Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $2,478,763

  • Health Canada Contribution

    $1,239,381

Project Overview

One of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA-binding protein 43 (TDP-43). As a result, understanding the mechanisms by which TDP-43 may influence the disease may have a tremendous impact…

Project Ongoing

See the project and researchers

Novel MRI biomarkers for monitoring disease progression in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $2,946,303

  • Health Canada Contribution

    $1,473,151

Project Overview

For this project Dr. Sanjay Kalra and his team aims to improve on current techniques to use magnetic resonance imaging (MRI) as a readily available way to examine if a potential new treatment is working to slow down progression of ALS. Preliminary work by Dr. Kalra has revealed that using…

Project Ongoing

See the project and researchers