Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach
Aperçu du projet
Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas where drugs can attach and rescue diseased cells. Once these areas are located, various drugs will be tested on the site to determine if the proteins can regain their normal functioning. If the experiments in this study are successful, the outcomes could support new dementia treatments in future.
Sriram Subramaniam , University of British Columbia
Partenaire et Donateurs
Alzheimer Society of Canada