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ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly Project...

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Project Overview The brain cells in Alzheimer’s disease patients differ...

Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Project Overview Infants born early (preterm) are at risk for brain injury and long term...

Epilepsy is a debilitating disease affecting 1% of the world’s population. Project Overview Epilepsy is a debilitating disease affecting 1% of the world’s population. It is characterized by an enduring propensity to recurring seizures. One of the cornerstones of the diagnosis and management of...

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective therapy to significantly slow...

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. Project Overview Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with...

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...

Attention Deficit Hyperactivity Disorder (ADHD) is the most common brain-related condition in children leading to challenges with attention and impulse control. As a result, children often struggle to stay focused or stop themselves from acting impulsively. Project Overview Attention Deficit...

We discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP. Project Overview We discovered that approximately one fifth of people with the deadly brain tumour...

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Project Overview RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to...