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Geometric Determinants of Hippocampal Spatial Encoding
https://braincanada.ca/fr/subventions-financées/geometric-determinants-of-hippocampal-spatial-encodingOur brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories. Project Overview Our brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories....
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Gold and BBB Opening in ALS (The GOALS Trial): A Phase 2a, Open-label, Single-arm Clinical Trial of Oral CNM-Au8 Coupled with Primary Motor Cortex Blood Brain Barrier Opening Using Transcranial MR-guided Focused Ultrasound in Amyotrophic Lateral Sclerosis
https://braincanada.ca/fr/subventions-financées/gold-and-bbb-opening-in-als-the-goals-trial-a-phase-2a-open-label-single-arm-clinical-trial-of-oral-cnm-au8-coupled-with-primary-motor-cortex-blood-brain-barrier-opening-using-transcranial-mr-guided-focused-ultrasound-in-amyotrophic-lateral-sclerosisRationale: Mitochondrial dysfunction has been identified as a contributing factor for bioenergetic dysregulation and neurodegeneration in the motor cortex and spinal cord of patients with ALS. Project Overview Rationale: Mitochondrial dysfunction has been identified as a contributing factor for...
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GPNMB CAR-T Cells as a Multi-Pronged Immunotherapeutic Approach for Glioblastoma
https://braincanada.ca/fr/subventions-financées/gpnmb-car-t-cells-as-a-multi-pronged-immunotherapeutic-approach-for-glioblastomaGlioblastoma (GBM) is the most common and deadly adult brain cancer. Project Overview Glioblastoma (GBM) is the most common and deadly adult brain cancer. GBM is particularly challenging because it contains many different cell types that help it grow and resist treatment, one of which are immune...
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Habitual physical activity, exercise and cardiovascular function in spinal cord injury
https://braincanada.ca/fr/subventions-financées/habitual-physical-activity-exercise-and-cardiovascular-function-in-spinal-cord-injuryThe major objectives of this research program are to measure the function of the heart and blood vessels following SCI and to investigate the mechanisms that are responsible for any changes that occur. Project Overview The major objectives of this research program are to measure the function of the...
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Harnessing beneficial aspects of neuroinflammation for regenerating the central nervous system
https://braincanada.ca/fr/subventions-financées/harnessing-beneficial-aspects-of-neuroinflammation-for-regenerating-the-central-nervous-systemThis research project, led by Dr. V. Wee Yong from the University of Calgary, focused on the immune system, which is comprised of two major components, the innate and adaptive systems. Innate immunity is the first immune component to sense and respond to an injury. Project Overview This research...
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Harnessing mRNA translation to increase the neuroprotective potential of disease-associated microglia in neurodegenerative diseases
https://braincanada.ca/fr/subventions-financées/harnessing-mrna-translation-to-increase-the-neuroprotective-potential-of-disease-associated-microglia-in-neurodegenerative-diseasesMicroglia are the brain’s immune cells. Project Overview Microglia are the brain’s immune cells. Research in recent years has revealed their crucial role in preventing the development of neurodegenerative diseases, including Alzheimer’s Disease (AD). However, the precise mechanisms by which...
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Health system implications of novel therapeutics for Alzheimer’s Disease: Supporting capacity planning with real-world evidence
https://braincanada.ca/fr/subventions-financées/health-system-implications-of-novel-therapeutics-for-alzheimer-s-disease-supporting-capacity-planning-with-real-world-evidenceClose to 600,000 Canadians currently live with Alzheimer’s disease and related dementias, but effective therapies are limited and focus on symptom management rather than a cure. Project Overview Close to 600,000 Canadians currently live with Alzheimer’s disease and related dementias, but effective...
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HEMO Trial
https://braincanada.ca/fr/subventions-financées/hemo-trialSpinal cord injury (SCI) leads to dramatic alterations in physical and mental well-being. Project Overview Spinal cord injury (SCI) leads to dramatic alterations in physical and mental well-being. It is well understood that people with severe SCI lose their ability to move. However, a lesser-known...
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High-throughput single-cell optophysiology and RNA sequencing to understand seizure initiation and intervention
https://braincanada.ca/fr/subventions-financées/high-throughput-single-cell-optophysiology-and-rna-sequencing-to-understand-seizure-initiation-and-interventionEpilepsy – a brain disorder defined by repeated seizures – imposes significant challenges for individuals and society. Project Overview Epilepsy – a brain disorder defined by repeated seizures – imposes significant challenges for individuals and society. One of the most challenging cases of...
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Hippocampal heterogeneity in health and disease
https://braincanada.ca/fr/subventions-financées/hippocampal-heterogeneity-in-health-and-diseaseThe brain is estimated to contain 100 billion cells that form 100 trillion connections. Project Overview The brain is estimated to contain 100 billion cells that form 100 trillion connections. Brain cells speak to each other by releasing chemicals into a small area known as the synapse, and...
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