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Mitochondria are cellular components which provide the energy required by the brain. Any alteration of these small engines can lead to brain disorders, but their role in dementia remains poorly understood. Project Overview Mitochondria are cellular components which provide the energy required by...

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the motor neurons degenerate, leading to symptoms of muscle weakness and progressive paralysis, resulting in the death of patients from respiratory failure. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a...

Attention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior cingulate cortex (ACC). Project Overview Attention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior...

Slow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with little to no conscious experience, such as coma, sleep, and anesthesia. Project Overview Slow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with...

Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. Project Overview Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The...

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or even...

Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. Project Overview Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. There is a recent and growing false belief that Cannabis can reduce nausea during...

Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. Project Overview Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few...

Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain cancer of childhood. Project Overview Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain...

Pediatric high-grade gliomas are incurable brain cancers. Project Overview Pediatric high-grade gliomas are incurable brain cancers. Sequencing the tumor specimens has shown that most cases do not have obvious mutations that are known to cause cancer. It is therefore not known what causes, or...