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In the era of climate change-related disasters and a globally disruptive pandemic, people worldwide are grappling with the question of how to foster resilience. Project Overview In the era of climate change-related disasters and a globally disruptive pandemic, people worldwide are grappling with...

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. Project Overview Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. To...

Alzheimer’s disease is the most common form of dementia. Project Overview Alzheimer’s disease is the most common form of dementia. The brains of many of the patients are less well supplied with glucose (sugar), but not much research aims to understand why this happens. Further, a protein of central...

Medulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. Project Overview Medulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. The treatment for medulloblastoma comprises...

Brain disorders are among the leading causes of death and disability worldwide, affecting about 3.6 million Canadians. While we know that genetics play an important role, the specific genetic causes remain unknown for most people with the disorders. Project Overview Brain disorders are among the...

The overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Project Overview The overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Specifically we will investigate...

Our brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories. Project Overview Our brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories....

Rationale: Mitochondrial dysfunction has been identified as a contributing factor for bioenergetic dysregulation and neurodegeneration in the motor cortex and spinal cord of patients with ALS. Project Overview Rationale: Mitochondrial dysfunction has been identified as a contributing factor for...

Glioblastoma (GBM) is the most common and deadly adult brain cancer. Project Overview Glioblastoma (GBM) is the most common and deadly adult brain cancer. GBM is particularly challenging because it contains many different cell types that help it grow and resist treatment, one of which are immune...

The major objectives of this research program are to measure the function of the heart and blood vessels following SCI and to investigate the mechanisms that are responsible for any changes that occur. Project Overview The major objectives of this research program are to measure the function of the...