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Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). Project Overview Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). It is important to understand how the regulation of mitochondria is impaired...

This proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. Project Overview his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse...

Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. Project Overview Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. However, the mechanisms underlying the...

Developmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC). Project Overview Developmental signaling...

“La bonne intervention, au bon moment, pour le bon enfant”. Project Overview “La bonne intervention, au bon moment, pour le bon enfant”. Le bien-être et l’amélioration des capacités adaptatives des enfants ayant des troubles du neurodéveloppement nécessitent des interventions personnalisées dans le...

Many childhood disorders, such as Autism Spectrum Disorder (ASD) or Fragile X Syndrome (FXS), are a result of abnormal growth and connections throughout the brain, rather than being caused by some specific pathology, such as a tumour. Project Overview Many childhood disorders, such as Autism...

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients. Project Overview Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of...

Need for project: The rate of success of a given treatment for brain cancer is dependent on early diagnosis followed by qualification for surgery, which to date remains as the course of treatment with the highest survival rate for brain cancer patients. Project Overview Need for project: The rate...

The serotonin transporter (5-HTT) is a protein that clears extracellular serotonin from the synapses and depletion of serotonin is associated with depressive symptoms. Project Overview The serotonin transporter (5-HTT) is a protein that clears extracellular serotonin from the synapses and depletion...

The fight against ALS is made extremely challenging due to its largely unknown origin in most patients. Project Overview The fight against ALS is made extremely challenging due to its largely unknown origin in most patients. This is the case for sporadic ALS, which accounts for up to 90% of all ALS...