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Amyotrophic Lateral Sclerosis (ALS) is a progressive disease that destroys the motor neurons needed for movement, speech, and breathing, but new research shows that other spinal cord cells called interneurons may be affected even earlier.

There is a lot of talk about the gut microbiome in neurology. This is important, because people with neurological diseases, including Alzheimer´s disease (AD), change their diets and think about probiotics when finding out about their diagnosis. Researchers study the gut microbiome by analyzing stool samples and then seeing if it is different in AD compared to healthy people. However, there is a major flaw in this research.

Timothy Friedman, a Postdoctoral Fellow at the University of British Columbia, is investigating the mechanisms through which DNA enables repair after injury in peripheral nerves but not the brain or spinal cord.

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

Sofia Gentile, a Master’s Student at University of Toronto, is investigating the role of immune cell activation in a rare and fatal neurodegenerative disease called progressive supranuclear palsy.

Lu Wang, a Doctoral Student at McGill University, aims to compare the predictive accuracy of family history and polygenetic risk score for multiple sclerosis.

Alzheimer’s disease (AD) is the most common cause of dementia, affecting memory, thinking, and daily functioning. AD is characterized by the buildup of two proteins, amyloid-β and tau. Specifically, tau protein is responsible for the loss of brain cells, leading to dementia. In addition to these two proteins, however, studies have also shown that inflammation plays an important role in how the disease develops and progresses.

Personalized Modeling and Optimization of Transcranial Temporal Interference Stimulation in Major Depressive Disorder

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that progressively destroys motor neurons, leading to paralysis and death, with no current cure.