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PRIME-RNA: A platform for in vivo preclinical testing of RNA therapeutics

RNA medicines—short strands of nucleic acids that can turn genes “up” or “down”—have changed how we treat brain diseases. For example, nusinersen for spinal muscular atrophy and tofersen for ALS are given by spinal injection to reach the brain and spinal cord. These breakthroughs show that RNA drugs work in the nervous system. However, before these treatments can reach patients, they must be tested in living systems to ensure safety and effectiveness.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Neurotechnology
Competition
2025 Platform Support Grants
Province
Québec
Start Date
2026

Neuronal polarity defects as an underlying cause of neurological diseases.

Neurons are cells with long extensions that send information from one part of the nervous system to another.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Central Nervous System
Competition
W. Garfield Weston Foundation - Brain Canada Multi-Investigator Research Initiative (MIRI)
Province
Québec
Start Date
2013