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Funded Grants

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4 results found

Investigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models

While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children.

Project ongoing See Project & Researchers
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models

CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2021

Generating expanded repeats in the C9ORF72 ortholog in zebrafish

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Career Transition Award
Province
Québec
Start Date
2017