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5 results found

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo

A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading frame 72), a gene of unclear function, is the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (C9-ALS/FTD).

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2022

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

Amyotrophic lateral sclerosis (ALS) is a terminal disease that paralyzes people because the brain is no longer able to communicate with the muscles that we are typically able to move at will.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
2019 Platform Support Grants
Province
Alberta
Start Date
2021

Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Ontario
Start Date
2017

Z-BRAIN: A Zebrafish Drug Screening Platform Targeting Brain Disorders

The traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Neurotechnology
Competition
2014 Platform Grants
Province
Ontario
Start Date
2015

Characterizing the C9ORF72 protein interactome for identifying novel pathogenic pathways in ALS

In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2015