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4 results found

Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis

This proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2024

Human inducible pluripotent stem cells (iPSC) platform

Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Neurotechnology
Competition
2014 Platform Grants
Province
Québec
Start Date
2015

Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers

One of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA–binding protein 43 (TDP-43).

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Québec
Start Date
2015

Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons).

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
2012 MIRI Team Grants
Province
British Columbia
Start Date
2014