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4 results found

Integrating multi-omics and neuroimaging to dissect crosstalk between the adaptive and innate immune systems in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common cause of dementia, affecting memory, thinking, and daily functioning. AD is characterized by the buildup of two proteins, amyloid-β and tau. Specifically, tau protein is responsible for the loss of brain cells, leading to dementia. In addition to these two proteins, however, studies have also shown that inflammation plays an important role in how the disease develops and progresses.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Accelerator Grants: Neurodegeneration x Immunology
Province
Québec
Start Date
2026

A Human System to study Immune-Ependymal Cell Relationships

Ependymal cells are a largely understudied barrier cell type in the brain that provide a wall between brain tissue and brain fluid (cerebral spinal fluid, CSF), playing an important role in regulating fluid balance.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2020

Evaluation of the pathogenic role of autoantibodies on ependymal cells in multiple sclerosis

Multiple sclerosis (MS) is a chronic disease that affects the brain, leading to difficulties with movement, thinking, and mood. While current treatments help reduce relapses, they often fail to prevent the steady worsening of disability that many people with MS experience over time.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research - Momentum Grants
Province
Québec

Untangling the adaptive immune response in PD

Parkinson’s disease (PD) is a common brain disorder that gradually affects movement, balance, and coordination. It mainly results from the loss of nerve cells that produce dopamine, a chemical that helps control motion.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Accelerator Grants: Neurodegeneration x Immunology
Province
Québec