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The University of British Columbia Genes, Cells and Circuits (UBC-GC2) platform for next-generation multiscale brain research

There is an urgent need for research that deepens our understanding of human brain function and uses this knowledge to accelerate therapeutic breakthroughs related to brain dysfunction.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Multiple
Competition
2024 Platform Support Grants
Province
British Columbia
Start Date
2025

Cytosolic DNA sensing in ALS-related neuroinflammation

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
British Columbia
Start Date
2021

Mechanisms of in vitro synaptic transmission of mis-folded human SOD1

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to another.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
British Columbia
Start Date
2017

A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
CQDM - Brain Canada - Focus on Brain
Province
Québec
Start Date
2016

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

A treatment or prevention of Alzheimer’s disease is a top priority for medical science.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
BC Alzheimer's Research Award Program
Province
British Columbia
Start Date
2015

Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons).

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
2012 MIRI Team Grants
Province
British Columbia
Start Date
2014