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Mapping Prodromal Brain Iron in Isolated Rapid Eye Movement Sleep Behavior Disorder to Forecast Parkinson’s Disease and Dementia with Lewy Bodies

Isolated REM sleep behavior disorder (iRBD) is a sleep condition where people physically act out dreams because the normal muscle “paralysis” of REM sleep is lost. It is confirmed by an overnight sleep study with video monitoring. iRBD matters because it is one of the strongest known early warning signs for future synucleinopathies (brain diseases linked to abnormal buildup of the protein alpha-synuclein) especially Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) (and less often multiple system atrophy, MSA).
Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2026

The SLEEP HUB: an open science ecosystem for transforming sleep research

The SLEEP HUB is an innovative platform aimed at advancing sleep research and fostering collaborations at various levels—local, national, and international.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Multiple
Competition
2024 Platform Support Grants
Province
Québec
Start Date
2025

Peripheral immune signatures of neurodegeneration in isolated REM sleep behavior disorder: an MRI-neuroinflammation study

When we dream, our bodies are normally paralyzed so we don’t act out the dream. In isolated REM sleep behavior disorder (iRBD), that safety switch fails: people may talk, shout, punch, or kick during sleep. iRBD is important because most people with it will later develop a brain disease like Parkinson’s disease or dementia with Lewy bodies.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Accelerator Grants: Neurodegeneration x Immunology
Province
Québec