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7 results found

The Canadian Optogenetics and Vectorology Foundry

Optogenetics, defined as a technique where light-sensitive genes are introduced into brain cells to control their activity with light, allows researchers to precisely control nerve cell communication thereby, transforming brain research.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Central Nervous System
Competition
2024 Platform Support Grants
Province
Québec
Start Date
2025

Designing synthetic extracellular matrices to support neurodegenerative disease modeling

We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture.

Project ongoing See Project & Researchers
Area of Research
Neurodegeneration
Competition
CQDM - Brain Canada - Call for Collaborative Research Projects on the Brain
Province
Québec
Start Date
2025

The application of 3D models to assess the role of microglia in neurodegenerative disorders

Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
CQDM - Brain Canada - Quantum Leap
Province
Québec
Start Date
2024

Modeling ALS progression by applying neuroinformatics to a novel in vitro human 3D tri-culture model of the disease

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the motor neurons degenerate, leading to symptoms of muscle weakness and progressive paralysis, resulting in the death of patients from respiratory failure.

Project ongoing See Project & Researchers
Grant type
Team grants
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2023

Canadian Optogenetics and Vectorology Foundry

Optogenetics is a relatively new science subdomain that is revolutionizing brain research with great promises for therapeutics.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Neurotechnology
Competition
2019 Platform Support Grants
Province
Québec
Start Date
2020

Development of a high throughput 3D microphysiologicalplatform for rapid automated assessment of human brain organoids response to drugs targeting neurological disorders

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating neurological diseases, with over 750,000 AD patients and over 100,000 PD patients in Canada.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
CQDM - Brain Canada - Quantum Leap
Province
Québec
Start Date
2020

A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
CQDM - Brain Canada - Focus on Brain
Province
Québec
Start Date
2016