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How does cellular stress impact TDP-43, a key ALS protein?

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
2025 ALS Canada - Brain Canada Trainee Program
Province
Ontario
Start Date
2026

How does cellular stress impact TDP-43, a key ALS protein?

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Clinical Research Fellowship 2025
Province
Ontario
Start Date
2025