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Beyond Exon 1: Exploring the Pathogenic Role of Novel Huntingtin Aggregates in vivo.

Mutations within exon 1 of the huntingtin (HTT) protein promote its aggregation and accumulation in the brain and periphery, ultimately driving neuronal dysfunction and the clinical manifestation of Huntington’s disease (HD). Although HTT is a large protein composed of more than 3,000 amino acids, exon 1 represents less than 3% of its total length. For decades, this small N-terminal fragment has been viewed as the principal driver of pathology. Yet HTT is far more than exon 1, and regions outside this domain can also undergo proteolytic processing, potentially generating toxic species whose contribution to disease remains poorly understood.
Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
2026 Huntington Society of Canada - Brain Canada Undergraduate Student Summer Fellowship
Province
Québec
Start Date
2026